Atherosclerosis Clinical Evaluation and Therapy : Proceedings of the Fourth International Meeting on Atherosclerosis held in Bologna, Italy 23-25 November 1981

This volume is the proceedings of the 4th International Congress on 'Arterio­ sclerosis; Etiopathogenesis, Clinical Evaluation and Therapy', held in Bologna. In the pages of this book you will find a record of all the themes developed by the various speakers at the Congress and closely studied by the many scientists who attended and who were concerned to learn about recent research develop­ ments in the arteriosclerosis field. In the sections that follow, the various trends in the different countries can be seen. The emphasis throughout is on clinical aspects of arteriosclerosis, and not merely on experimental laboratory studies. This is particularly important at a time when the technology is improving and so sometimes seems to command more attention than actual clinical observations. A careful researcher of arteriosclerosis will be able to see from the results of epidemiological, experimental, nutritional and clinical surveys (addressed more towards controlling physiological behaviour through life habits than through drugs) the best course to take in defining and controlling­ with maximum precision - the progression of arteriosclerosis disease. Professor Sergio Lenzi Professor Giancarlo Descovich xix SECTION 1 Atherosclerosis risk factors and their influence on cardiovascular diseases BACKGROUND PAPER 1 Atherosclerosis today A. M. COTTO, Jr. RISK FACTORS The three major risk factors for coronary artery disease are hypercholesterol­ aemia, hypertension and cigarette smoking. I will focus on lipids and lipo­ proteins but would also like to make a few comments about other risk factors. Content: Front Matter....Pages i-xix Front Matter....Pages 1-1 Atherosclerosis today....Pages 3-15 Plasma lipid and lipoprotein distribution in a Jerusalem population sample. Genetic and environmental effects; preliminary report....Pages 17-21 So-called minor risk factors in atherogenesis....Pages 23-27 Cardiovascular risk in obesity....Pages 29-39 Lipoprotein alterations in alcoholics....Pages 41-46 Hyperuricaemia and atherosclerosis....Pages 47-52 Atherosclerosis and orthostatic arterial hypotension....Pages 53-60 The epidemiology of high density lipoproteins: The Lipid Research Clinics Program Prevalence Study....Pages 61-75 Front Matter....Pages 77-77 Possible connections between classic and new aetiopathogenetic tendencies in coronary heart disease....Pages 79-90 Ultrastructural views during myocardial ischaemia....Pages 91-93 Provocative tests for coronary arterial spasm in patients with ischaemic heart disease....Pages 95-102 Altered arachidonic acid metabolism in platelets and in vessel wall in patients with ischaemic heart disease....Pages 103-111 Fatty-acid transport in the myocardium....Pages 113-117 The ischaemic area: evaluation and attempts to limit extension....Pages 119-129 The good and bad of lowering serum cholesterol....Pages 131-138 Front Matter....Pages 139-139 Atherosclerosis in the world: the European point of view....Pages 141-154 Heart-brain relationship: cerebral ischaemia in six additional cases with mitral-valve prolapse....Pages 155-158 Cerebral circulation and metabolism with positron emission tomography: ischaemia redefined?....Pages 159-164 Cerebral ischaemia: systemic risk factors and their prevention....Pages 165-169 Clinical and neuropsychological aspects of chronic cerebrovascular disorders....Pages 171-175 Front Matter....Pages 139-139 Treatment and pathogenesis of cerebrocircular disturbances in patients with heart disease and arrhythmia....Pages 177-185 Therapeutic prospects of acute cerebral ischaemia....Pages 187-201 Front Matter....Pages 203-203 Dietary proteins and atherosclerosis....Pages 205-215 Experimental and clinical studies on the cholesterol lowering activity of the soybean protein diet....Pages 217-224 Hypocholesterolaemic effects of soy protein in relation to amino-acid composition: experimental researches....Pages 225-230 Hormonal effects of soybean protein diet....Pages 231-242 Hepatobiliary effects of soybean protein diet....Pages 243-248 Treatment of hypercholesterolaemic patients with soybean protein....Pages 249-265 Front Matter....Pages 267-267 Exercise electrocardiograms in the diagnosis of coronary artery disease....Pages 269-282 Radionuclide techniques in the study of ischaemic heart disease....Pages 283-295 Diagnostic visualization of ischaemic myocardium....Pages 297-311 Front Matter....Pages 313-313 The role of dietary polyunsaturated fatty acids and prostaglandins in reducing blood pressure and improving thrombogenic indices....Pages 315-332 Epidemiology and prevention of coronary heart disease in North Karelia: results from the North Karelia project and associated studies with special reference to nutrition and serum cholesterol....Pages 333-341 Coronary risk factors and mortality for coronary and non-coronary events....Pages 343-351 Precursors of atherosclerosis in children; the Cittadella Study: familial aggregation of serum cholesterol....Pages 353-356 The Brisighella Study....Pages 357-366 Lipoprotein profile in a group of young people on regular physical activity (ISEF study)....Pages 367-372 Front Matter....Pages 373-373 Brain ageing and dopaminergic drugs: a possible pharmacological profile for suloctidil....Pages 375-382 Clinical study on the action of suloctidil in cerebrovascular syndromes. A multi-centre investigation....Pages 383-399 Treatment of chronic cerebrovascular disorders....Pages 401-405 Front Matter....Pages 373-373 Association of surgical and medical therapy in cerebral ischaemia....Pages 407-421 Medical treatment of peripheral vascular disease....Pages 423-436 Suloctidil in intermittent claudication: clinical and plethysmographic results....Pages 437-442 Front Matter....Pages 443-443 Metabolic and haemorheological aspects in ischaemia of the lower limbs....Pages 445-452 The identification of the variation of atherosclerosis plaques by invasive and non-invasive methods....Pages 453-465 Coronary artery bypass as treatment in angina pectoris....Pages 467-471 Surgery in the therapy of atherosclerosis: partial ileal bypass....Pages 473-484 Concluding remarks....Pages 485-487 Back Matter....Pages 489-498