Artificial Oxygen Carrier: Its Frontline (Keio University International Symposia for Life Sciences and Medicine, Vol. 12) (Keio University International Symposia for Life Sciences and Medicine)

While a reliable supply of donated blood is vital in modern medicine, it remains the case that blood transfusion comes with its own problems, such as infectious diseases, immunological adverse reactions, and difficulties with long-term storage and transportation of blood components. With a view to solving these problems, developing a suitable blood substitute has been a major goal for decades. Artificial Oxygen Carrier: Its Front Line is a compilation of reports on the concepts behind artificial oxygen carriers, as well as the new discoveries in the field that were presented during the 13th Keio International Symposium for Life Science and Medicine. This volume describes valuable topics, including artificial red blood cells, modified haemoglobin, perfluorocarbons, and haemoglobin vesicles. It explains cutting-edge developments in artificial oxygen carrier research and will be a valuable resource to all concerned with the field. Cover......Page 1 00Fronter......Page 2 01Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes..pdf......Page 16 02Red Blood Cell Substitutes Past, Present, and Future..pdf......Page 37 03Inhaled Nitric Oxide Update 2003..pdf......Page 49 04The Role of p50 in Tissue Oxygen Delivery by Cell-Free Oxygen Carriers..pdf......Page 53 05Repetitive Administration of Hemoglobin Raffimer in Experimental Models and Clinical Applications..pdf......Page 68 06Oxygen Gradients In Vivo Seen by a High Oxygen Affinity HB Polymer..pdf......Page 77 07Oxygen Partition Between Microvessels and Tissue Significance for the Design of Blood Substitutes..pdf......Page 85 08Endothelial Cell Response to Hemoglobin Based Oxygen Carriers..pdf......Page 90 09The Development of a Second-Generation, Designer, Recombinant Hemoglobin..pdf......Page 142 10Hemoglobin-Vesicles (HbV) as Artificial Oxygen Carriers..pdf......Page 150 11Successful Ex Vivo Normothermic Liver Perfusion with Purely Artificial Products Using Artificial Blood..pdf......Page 184 12Effect of Hemoglobin-Based Blood Substitutes on Nitric Oxide Transport Mathematical Models..pdf......Page 191 13New Strategy for the Preparation of NO-Treated Red Blood Cells as a Blood Substitute..pdf......Page 201 14Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme..pdf......Page 208 15Micromechanical Properties of Newly Developed Polyelectrolyte Microcapsules (PEMC)..pdf......Page 220 16Intravascular Microbubbles An Ultra-Effective Means of Transporting Oxygen..pdf......Page 232 17Oxygen-Dependent and Oxygen-Independent Effects of Perftoran..pdf......Page 236 18State of the Art and Challenges in Blood Substitutes Research A Case Study on Perfluorocarbon-Based Oxygen Carriers..pdf......Page 244 19Semifluorinated Alkanes as Stabilizing Agents of Fluorocarbon Emulsions..pdf......Page 252 20Possible Role of Artificial Oxygen Carriers in Shock and Trauma..pdf......Page 267 21Clinical Needs for Artificial Oxygen Carriers in Anaesthesia..pdf......Page 274 22Studies on Red Cell Substitutes in Japan and Future Perspectives..pdf......Page 282 Index......Page 294 This volume of the Keio University International Symposia for Life Sciences and Medicine contains the proceedings of the 13th symposium held under the sponsorship of the Keio University Medical Science Fund. The fund was est- lished by the generous donation of the late Dr. Mitsunada Sakaguchi. The Keio University International Symposia for Life Sciences and Medicine constitute one of the core activities sponsored by the fund,of which the objective is to contribute to the international community by developing human resources, promoting scienti?c knowledge, and encouraging mutual exchange. Each year, the Committee of the International Symposia for Life Sciences and Medicine selects the most signi?cant symposium topics from applications received from the Keio medical community. The publication of the proce- ings is intended to publicize and distribute the information arising from the lively discussions of the most exciting and current issues presented during the symposium. On behalf of the Committee, I am most grateful to the late Dr. Sakaguchi, who made the series of symposia possible. We are also grateful to the prominent speakers for their contribution to this volume. In addition, we would like to acknowledge the ef?cient organizational work performed by the members of the program committee and the staff of the fund. Naoki Aikawa, M. D. , D. M. Sc. , F. A. C. S. For human beings to survive, it is necessary to continuously deliver oxygen that is needed for the respiration of all tissue cells. K. Kobayashi, E. Tsuchida, H. Horinouchi (eds.). Includes Bibliographical References And Index.