Aromatase Inhibitors: Types, Mode of Action and Indications : Types, Mode of Action and Indications

Aromatase inhibitors (AI) are a class of drugs used in the treatment of breast cancer and ovarian cancer in postmenopausal women. Aromatase is an enzyme that synthesizes estrogen and aromatase inhibitors block the synthesis of estrogen, which is needed in some cancers to grow. As breast tissue is stimulated by estrogens, decreasing their production is a way of suppressing recurrence of the breast tumor tissue. In contrast to pre-menopausal women, in whom most of the estrogen is produced in the ovaries, in post-menopausal women most of the body's estrogen is produced in the adrenal gland from the conversion of androgens. Investigations are ongoing to look for other applications and researchers continue to study aromatase inhibitors as a way to stimulate ovulation or suppress estrogen production in endometriosis. This new book presents the latest research from around the world in this dynamic field. Anti-estrogen agents : aromatase inhibitors; past, present and future / Masanori Shimodaira and Tomohiro Nakayama Aromatase inhibitors : types, mode of action and indications / Helena Aguilar and Ander Urruticoechea Aromatase inhibitors / Mosammat Rashida Begum and Maruf Siddiqui Upfront vs. sequential aromatase inhibitors : an ongoing or settled debate? / Tallal Younis and Chris Skedgel Aromatase expression in the endometrium and its role in the development of uterine pathology / Hugo Maia Jr ... [et al.] Aromatase inhibitors for the medical treatment of endometriosis / Kaei Nasu ... [et al.] An update of the use of aromatase inhibitors in the management of breast cancer / S. Tang, D.A.L. Morgan, and K.L. Cheung Aromatase inhibitors in ovulation induction : myth or reality? / Nikolaos P. Polyzos ... [et al.] The use of aromatase inhibitors in ovarian cancer and identification of responsive tumors / S.P. Langdon ... [et al.]. Anti-estrogen agents : aromatase inhibitors; past, present, and future / Masanori Shimodaira and Tomohiro Nakayama Aromatase inhibitors : types, mode of action, and indications / Helena Aguilar and Ander Urruticoechea Aromatase inhibitors / Mosammat Rashida Begum, Maruf Siddiqui Upfront vs. sequential aromatase inhibitors : an ongoing or settled debate? / Tallal Younis ... [et al.] Aromatase expression in the endometrium and its role in the development of uterine pathology / Hugo Maia Jr ... [et al.] Aromatase inhibitors for the medical treatment of endometriosis / Kaei Nasu ... [et al.] An update of the use of aromatase inhibitors in the management of breast cancer / S. Tang, D.A.L. Morgan, and K.L. Cheung Aromatase inhibitors in ovulation induction : myth or reality? / Nikolaos P. Polyzos ... [et al.] The use of aromatase inhibitors in ovarian cancer and identification of responsive tumors / S.P. Langdon ... [et al.].