Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents

This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto, and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents, nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions. Psychotropic medications from different categories are frequently prescribed together, or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result. The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology. Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions, isfrequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents Front Matter....Pages i-xiv Front Matter....Pages 1-1 Pharmacokinetic Properties....Pages 3-27 Pharmacodynamics....Pages 29-48 Positron Emission Tomography (PET) Use in Pharmacology....Pages 49-70 Population Pharmacokinetics....Pages 71-90 Drug Transporters....Pages 91-119 Pharmacogenomics....Pages 121-135 Front Matter....Pages 137-137 Antipsychotics....Pages 139-175 Mood Stabilizers....Pages 177-203 Antidepressants....Pages 205-245 Clinical Pharmacokinetics and Pharmacodynamics of Anxiolytics and Sedative/Hypnotics....Pages 247-266 Opioid Analgesics....Pages 267-301 Stimulants and Other Non-stimulants for Attention-Deficit/Hyperactivity Disorder (ADHD)....Pages 303-327 Antidementia Drugs....Pages 329-349 Anti-addiction Agents....Pages 351-372 Anesthetic Drugs Pharmacokinetics and Pharmacodynamics....Pages 373-394 Front Matter....Pages 395-395 Clinically Significant Interactions with Antipsychotics....Pages 397-421 Clinically Significant Interactions with Mood Stabilisers....Pages 423-449 Clinically Significant Interactions with Antidepressants....Pages 451-469 Clinically Significant Interactions with Benzodiazepines....Pages 471-495 Clinical Significant Interactions with Opioid Analgesics....Pages 497-534 Front Matter....Pages 395-395 Clinically Significant Interactions with Stimulants and Other Non-stimulants for ADHD....Pages 535-549 Clinically Significant Interactions with Cholinesterase Inhibitors and Other Antidementia Agents....Pages 551-563 Clinically Significant Interactions with Anti-addiction Agents....Pages 565-577 Clinically Significant Interactions with Anesthetic Agents....Pages 579-601