Applications of Calorimetry in a Wide Context - Differential Scanning Calorimetry, Isothermal Titration Calorimetry and Microcalorimetry

Calorimetry, as a technique for thermal analysis, has a wide range of applications which are not only limited to studying the thermal characterisation (e.g. melting temperature, denaturation temperature and enthalpy change) of small and large drug molecules, but are also extended to characterisation of fuel, metals and oils. Differential Scanning Calorimetry is used to study the thermal behaviours of drug molecules and excipients by measuring the differential heat flow needed to maintain the temperature difference between the sample and reference cells equal to zero upon heating at a controlled programmed rate. Microcalorimetry is used to study the thermal transition and folding of biological macromolecules in dilute solutions. Microcalorimetry is applied in formulation and stabilisation of therapeutic proteins. This book presents research from all over the world on the applications of calorimetry on both solid and liquid states of materials. Cover......Page 1 Applications of Calorimetry in a Wide Context: Differential Scanning Calorimetry, Isothermal Titration Calorimetry and Microcalorimetry......Page 2 ©......Page 3 Contents......Page 5 Preface......Page 9 Section 1 Application of Differential Scanning Calorimetry into Pharmaceuticals......Page 11 1 Application of Differential Scanning Calorimetry to the Characterization of Biopolymers......Page 13 2 Thermal Stability of the Nanostructured Powder Mixtures Prepared by Mechanical Alloying......Page 31 3 Studies on Growth, Crystal Structure and Characterization of Novel Organic Nicotinium Trifluoroacetate Single Crystals......Page 59 Section 2 Application of Isothermal Titration Calorimetryf or Analysis of Proteins and DNA......Page 81 4 Isothermal Titration Calorimetry: Thermodynamic Analysis of the Binding Thermograms of Molecular Recognition Events by Using Equilibrium Models......Page 83 5 Applications of Calorimetric Techniques in the Formation of Protein-Polyelectrolytes Complexes......Page 115 6 Insights into the Relative DNA Binding Affinity and Preferred Binding Mode of Homologous Compounds Using Isothermal Titration Calorimetry (ITC)......Page 139 7 Thermodynamic Signatures of Macromolecular Complexes ‒ Insights on the Stability and Interactions of Nucleoplasmin, a Nuclear Chaperone......Page 163 Section 3 Application of MicroCalorimetry to Study Protein Stability and Folding Reversibility......Page 193 8 Determination of Folding Reversibility of Lysozyme Crystals Using Microcalorimetry......Page 195 9 Calorimetric Study of Inulin as Cryo- and Lyoprotector of Bovine Plasma Proteins......Page 207 Section 4 Thermal Analysis of Phase Transitions of Polymers and Paraffinic Wax......Page 229 10 Silver Particulate Films on Compatible Softened Polymer Composites......Page 231 11 Liquid-Solid Phase Equilibria of Paraffinic Systems by DSC Measurements......Page 263 12 Thermal Analysis of Phase Transitions and Crystallization in Polymeric Fibers......Page 287 Section 5 Indirect Calorimetry to Measure Energy Expenditure......Page 317 13 Energy Expenditure Measured by Indirect Calorimetry in Obesity......Page 319 Section 6 Applications of Calorimetry into Propellants, Alloys, Mixed Oxides and Lipids......Page 333 14 Thermal Decomposition Kinetics of Aged Solid Propellant Based on Ammonium Perchlorate – AP/HTPB Binder......Page 335 15 Numerical Solutions for Structural Relaxation of Amorphous Alloys Studied by Activation Energy Spectrum Model......Page 353 16 Thermal Analysis of Sulfur and Selenium Compounds with Multiple Applications, Including Anticancer Drugs......Page 375 17 Calorimetric Determination of Heat Capacity, Entropy and Enthalpy of Mixed Oxides in the System CaO–SrO–Bi2O3–Nb2O5–Ta2O5......Page 395 18 Differential Scanning Calorimetry Studies of Phospholipid Membranes: The Interdigitated Gel Phase......Page 417 19 Oxidative Stability of Fats and Oils Measured by Differential Scanning Calorimetry for Food and Industrial Applications......Page 455