Application of Transition Metal Catalysts in Organic Synthesis (Springer Laboratory)

Homogeneous catalysis is an important strategy for the synthesis of high-valued chemicals. L. Brandsma has carefully selected and checked the experimental procedures illustrating the catalytic use of copper, nickel, and palladium compounds in organic synthesis. All procedures are on a preparative scale, make economic use of solvents and catalysts, avoid toxic substances and have high yields. Front page ......Page 1 Preface......Page 6 Table of Contents......Page 7 1 Catalysts, Ligands and Reagents......Page 20 2 Procedures for the Preparation of Halogen Compounds......Page 37 3 Cross-Coupling Between 1-Alkynes and 1-Bromoalkynes......Page 66 4 Copper-Catalyzed Aminoalkylation of Acetylenes......Page 78 5 Copper(l)-Halide-Catalyzed Oxidative Coupling of Acetylenes......Page 84 6 Copper(I)-Halide-Catalyzed Substitution of sp2-Halogen by Alkoxide......Page 102 7 Copper-Catalyzed Carbon-Carbon Bond Formation by 1,1- and 1,3-Substitution Reactions......Page 123 8 Nickel Catalyzed lodo-Dechlorination and lodo-Debromination of sp2-Halides......Page 156 9 Nickel- and Palladium-Catalyzed Cyanation of sp2-Halides and sp2- Triflates......Page 164 10 Couplings of Acetylenes with sp2-Halides......Page 193 11 Nickel- and Palladium-Catalyzed Cross-Coupling Reactions with Organometallic Intermediates......Page 240 Index of Reaction Types......Page 326 Index of Experimental Procedures......Page 328 Complementary Subject Index......Page 340 This laboratory manual for synthetic organic chemists offers a selection of procedures using copper, nickel, and palladium compounds in homogeneous catalytical reactions. All procedures reported have been carefully checked in the authors' laboratory and are fully outlined for the use by graduate students in organic chemistry.