Application of biological markers to carcinogen testing [proceedings of the Symposium on the Application of Biological Markers to Carcinogen Testing held November 15-19, 1982, in Bethesda, Maryland

Front Matter....Pages i-xi Welcoming Remarks....Pages 1-2 An Overview of Current Research Efforts on the Application of Biological Markers to Carcinogen Testing....Pages 3-5 Chairman’s Overview on In Vivo Tests....Pages 7-8 The Occurrence Of Neoplasms in Long-Term in Vivo Studies....Pages 9-23 Markers of Liver Neoplasia — Real or Fictional?....Pages 25-42 Early Morphologic Markers of Carcinogenicity in Rat Pancreas....Pages 43-60 Rodent and Human Models For the Analysis of Intestinal Tumor Development....Pages 61-89 Effect Of Diet On Intestinal Tumor Production....Pages 91-107 Tumor Antigens As Markers For Carcinogens....Pages 109-115 Chairmen’s Overview on in Vitro Tests....Pages 117-118 Biochemistry and Biology of 2-Acetyl-Aminofluorene in Primary Cultures of Adult Rat Hepatocytes....Pages 119-133 Relating in Vitro Assays of Carcinogen-Induced Genotoxicity to Transformation of Diploid Human Fibroblasts....Pages 135-152 Evaluation of Chronic Rodent Bioassays and Ames Assay Tests as Accurate Models for Predicting Human Carcinogens....Pages 153-163 Indices for Identification of Genotoxic and Epigenetic Carcinogens in Cell Culture....Pages 165-175 Chairmen’s Overview on Enzyme Markers....Pages 177-178 Aryl Hydrocarbon Hydroxylase Activity “Of Mice and Humans”....Pages 179-197 Gamma-Glutamyl Transpeptidase Expression in Neoplasia and Development....Pages 199-220 Ornithine Decarboxylase: Alterations In Carcinogenesis....Pages 221-228 Human Tumors: Enzyme Activities And Isozyme Profiles....Pages 229-247 Enzyme and Isoenzyme Patterns as Potential Markers of Neoplasia in Breast Tissue....Pages 249-265 Chairmen’s Overview On Oncodevelopmental Markers....Pages 267-269 Alphafetoprotein as a Marker for Early Events and Carcinoma Development During Chemical Hepatocarcinogenesis....Pages 271-293 Human Chorionic Gonadotropin and its Subunits as Tumor Markers....Pages 295-311 Prostaglandins and Cancer....Pages 313-319 Chairmen’s Overview on the Use of Immunoanalytical Method for the Characterization and Quantification of DNA Components Structurally Modified by Carcinogens and Mutagens....Pages 321-324 Immunological Approaches for the Detection of DNA Modified by Environmental Agents....Pages 325-336 Detection of Thymine Dimers in DNA with Monoclonal Antibodies....Pages 337-348 Immunological Studies on the Influence of Chromatin Structure on the Binding of a Chemical Carcinogen to the Genome....Pages 349-371 High-Affinity Monoclonal Antibodies Specifically Directed Against DNA Components Structurally Modified by Alkylating N-Nitroso Compounds....Pages 373-385 Charimen’s Overview on Carcinogen-Induced Modification in DNA....Pages 387-388 Use of Repair-Deficient Mammalian Cells for the Identification of Carcinogens....Pages 389-402 Thymine Modifications in DNA as Markers of Radiation Exposure....Pages 403-415 Aberrant Methylation of DNA As an Effect of Cytotoxic Agents....Pages 417-426 Identification of Carcinogen-DNA Adducts by Immunoassays....Pages 427-440 Chairman’s Overview on Integration and Expression of the Polyoma Virus Oncogenes In Transformed Cells....Pages 441-452 Activation of Cellular Onc (C-ONC) Genes: A Common Pathway for Oncogenesis....Pages 453-463 Hepatitis B Virus as an Environmental Carcinogen....Pages 465-473 Research Needs on the Use of Tumor Markers in the Identification of Chemical Carcinogens....Pages 475-487 The Polypeptides of the Cytosol of Hepatocyte Nodules may Exhibit a Unique Electrophoretic Pattern....Pages 489-489 Rat Alloantigens as Cellular Markers for Hepatocytes in Genotypic Mosaic Livers During Chemically Induced Hepatocarcinogenesis....Pages 490-490 Metabolic Considerations in the Toxicity and Mutagenicity of the Nitronaphthalenes....Pages 491-492 Detection and Identification of Common Oncofetal Antigens on in Vitro Transformed Mouse Fibroblasts....Pages 493-493 Inhibition of Metabolic Cooperation Between Cultured Mammalian Cells by Selected Tumor Promoters, Chemical Carcinogens, and Other Compounds....Pages 494-495 A Rapid in Vitro Assay for Detecting Phorbol Ester-Like Tumor Promoters....Pages 496-497 Induction of Endogenous Murine Retrovirus by Chemical Carcinogens....Pages 498-498 In Utero Induction of Sister Chromatid Exchanges to Detect Transplacental Carcinogens....Pages 499-500 Evaluation of Known Genotoxic Agents and Δ 9 -Tetrahydrocannabinol for SCE Induction by the Intraperitoneal 5-Bromo-2’-Deoxyuridine Infusion Technique for Sister Chromatid Exchange Visualization....Pages 501-502 Effect of 2,3-Oxide-3,3,3-Trichloropropane on BaP Metabolism in Mullet....Pages 503-503 The Effect of Dimethylbenzanthracene on the NK Activity of Mice....Pages 504-505 Back Matter....Pages 507-516