Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases

As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer. Apoptotic Pathways And Their Regulation / Greet Brouckaert [and Others]. Summary. Apoptotic Pathways And Their Regulation. Antiapoptotic Pathways. Nonapoptotic Forms Of Cell Death -- Mechanisms Of Anticancer Drug Action / Sebastian Wesselborg And Kirsten Lauber. Summary. Introduction. The Major Apoptosis Signaling Pathways. Mechanisms Of Anticancer Drug Induced Apoptosis. Conclusions -- Death Receptor Pathways As Targets For Anticancer Therapy / Simone Fulda And Klaus-michael Debatinches Summary. Introduction. Apoptosis Signaling Pathways. Death Receptors. Signaling Through Death Receptors In Cancer Therapy. Defective Death Receptor Signaling In Cancer. Death Receptor-targeted Therapies For Cancer. Conclusions. Caspases; Modulators Of Apoptosis And Cytokine Maturation -- Targets For Novel Therapies / Melissa J. Knight And Christine J. Hawkins. Introduction. Indications For Caspase Activity Modulation. Considerations For Therapeutic Caspase Inhibitor Design. Conclusions -- The Intrinsic (mitochondrial) Death Pathway And New Cancer Therapeutics: Bcl-2 Family In Focus / Sanjeev Shangary, Christopher L. Oliver, And Daniel E. Johnson. Introduction. Mitochondrial Events Associated With The Intrinsic Apoptotic Pathway. The Intrinsic Mitochondrial Pathway Of Cell Death: Regulation By The Bcl-2 Protein Family. Dysregulation Of The Bcl-2 Family And Cancer. Targeting The Bcl-2 Protein Family For Anti-cancer Therapeutics. Survivin, Other Iaps, Smac/diablo, And Om1/htra2 -- Modulation Of The Advancing Apoptotic Process / Fengzhi Li. Introduction. Survivin As A Therapeutic Target. Other Iaps As Therapeutic Targets. Smac/diablo And Om1/htra2: What Is The Difference In Their Functions?. Summary -- The Life Cycle Of P53: A Key Target In Drug Development / Lee E. Finlan And Ted R. Hupp. Summary. Introduction. Drug Targets In The P53 Pathway. Conclusion -- Growth Factors, Receptors, And Kinases: Their Exploration To Target Cancer / Jennifer G. Brown And Spencer B. Gibson. Introduction. Growth Factors As A Survival Signal. Cell Surface Receptors. Signaling Pathways. Targets For Cancer Therapy. Summary. Targets For Apoptotic Intervention In Rheumatoid Arthritis / Steven C. Ghivizzani, Elvire Gouze And Jean-noel Gouze. Introduction. Apoptotic Pathways In Rheumatoid Arthritis. Target Cells For Intervention In Rheumatoid Arthritis. Experimental Treatments For Ra Involving Apoptosis. Conclusion -- Therapeutic Inhibition Of Apoptosis Caused By Stroke / Seth Love. Introduction. Ischaemic Injury And Consequences. Scope For Therapeutic Intervention. Conclusion -- Monoclonal And Bispecific Antibodies As Novel Therapeutics / Gundram Jung [and Others]. Introduction. Naked Antibodies. Armed Antibodies. Biomimetic, Bispecific Antibodies And The Bispecific Principle. Target Cell Restricted Activation Of The Cd95 Death Receptor With Bispecific Antibodies. Defined Sensitizers May Support Cd95 Mediated Apoptosis. Possible Pleiotropic Effects Of Tumor X Cd95-bispecific Antibodies. Changing Death Receptors And The Bispecific Format. Blocking Cd95 Mediated Apotosis With Antibodies. Conclusions. Targeting The Proteasome In Cancer Therapy / Robert Z. Orlowski. Introduction. The Ubiqutin-proteasome Pathway. Anti-tumor Activity Of Proteasome Inhibitors. Combining Proteasome Inhibition With Other Therapies. Anti-apoptotic Effects Of Proteasome Inhibitors. Proteasome Inhibition In The Clinical Arena. Conclusions -- D-rnai-based Therapeutics / Shi-lung Lin And Shao-yao Ying. Introduction. Development Of Dna-rna Interference. In Vitro Therapeutic Model For Prostate Cancer. Potential Gene Silencing Mechanisms. Vector-based D-rnai Effects In Vitro. In Vivo D-rnai Phenomena. Ex Vivo Therapy Against Hiv-1 Infection. Multiple Gene Approach For Cancer Therapy. Conclusion. Strategies Of Protection Of Normal Cells During Chemo- And Radio-therapy Based On Modulation Of Cell Cycle And Apoptic Pathways / Mikhail V. Blagosklonny And Zbigniew Darzynkiewicz. Introduction. Cyclotherapy: Combining Selective Cytostatic Agents With Chemotherapy That Targets Proliferating Cells. Autonomous Growth Of Cancer Cells. Historical Perspective On Protection Of Normal Cells. Transforming Growth Factor Beta (tgf-[beta]) For Protection Of Normal Cell. Inhibitors Of Mitogenic Kinases And Autonomous Growth. Mechanism-based Cytostatic Agents Protect. Two Birds With One Stone: Selective Sensitization To Apoptosis. Third Bird With The Same Stone: Inhibition Of Angiogenesis. Inhibition Of Mitogen-activated Signaling Sensitizes Cancer Cells To Chemotherapy. Conclusions -- Summary Table: New Therapeutic Agents Designed By Exploring The Recent Progress On Our Understanding Of Cell Death Pathways. Edited By Marek Los And Spencer B. Gibson. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Apoptotic Pathways and Their Regulation....Pages 1-29 Mechanisms of Anticancer Drug Action....Pages 31-55 Death Receptor Pathways As Targets for Anticancer Therapy....Pages 57-78 Caspases; Modulators of Apoptosis and Cytokine Maturation — Targets for Novel Therapies....Pages 79-106 The Intrinsic (Mitochondrial) Death Pathway and New Cancer Therapeutics: Bcl-2 Family in Focus....Pages 107-135 Survivin, other IAPs, Smac/Diablo, and Omi/Htra2 — Modulation of the Advancing Apoptotic Process....Pages 137-155 The Life Cycle of P53: A Key Target in Drug Development....Pages 157-172 Growth Factors, Receptors, and Kinases: Their Exploration to Target Cancer....Pages 173-195 Targets for Apoptotic Intervention in Rheumatoid Arthritis....Pages 197-212 Therapeutic Inhibition of Apoptosis Caused by Stroke....Pages 213-228 Monoclonal and Bispecific Antibodies as Novel Therapeutics....Pages 229-242 Targeting the Proteasome in Cancer Therapy....Pages 243-274 D-RNAi-Based Therapeutics....Pages 275-295 Nuclear Transcription Factor-κB: A Drug Target for all Seasons....Pages 297-322 Monitoring of Programmed cell Death in Vivo and in Vitro ,—New and Old Methods of Cancer Therapy Assessment....Pages 323-341 Current Strategies in Tumor-Targeting....Pages 343-355 Strategies of Protection of Normal Cells During Chemo- and Radio-Therapy Based on Modulation of Cell Cycle and Apoptotic Pathways....Pages 357-376 Apoptosis is the major cell death pathway used to remove unneeded and harmful cells in a clean and orderly manner during embryonic development, tissue homeostasis and immune regulation (Cohen, 1991; Ellis, et al., 1991).