Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development)

Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death, followed by chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third part covers DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth delves into Resistance and Sensitization. The book concludes with Established Cancer Therapies and a section which looks toward the future with Recent and Developing Cancer Therapies. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence. Front Matter....Pages I-XVII Front Matter....Pages 1-1 The Intrinsic Pathway of Apoptosis....Pages 3-30 The Extrinsic Pathway of Apoptosis....Pages 31-54 Mitotic Catastrophe....Pages 55-72 Autophagy and Autophagic Cell Death....Pages 73-91 Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis....Pages 93-107 Front Matter....Pages 109-122 Structure and Function of the Telomere....Pages 123-123 Overview of Senescence....Pages 125-144 Contributions of Telomerase to Tumorigenesis....Pages 145-157 The Role of Telomeres in Genomic Instability....Pages 159-171 Front Matter....Pages 173-189 Overview of the DNA Damage Checkpoint....Pages 191-191 DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy....Pages 193-221 Front Matter....Pages 223-241 Resistance/Signaling Pathways....Pages 243-263 Ceramide and Multidrug Resistance....Pages 265-278 Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling....Pages 279-279 The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy....Pages 281-298 Front Matter....Pages 299-312 Antimetabolites....Pages 313-334 Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes....Pages 335-357 Front Matter....Pages 359-359 Perturbations of Cellular Functions by Topoisomerase II Inhibitors....Pages 361-382 The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs....Pages 383-406 Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents....Pages 359-359 Tyrosine Kinase Inhibitors....Pages 407-422 Front Matter....Pages 423-463 Monoclonal Antibodies in Lymphomas....Pages 465-476 Role of Apoptosis in Anti-Angiogenic Cancer Therapies....Pages 477-508 Photodynamic Therapy-Induced Apoptosis....Pages 509-509 Modulation of TRAIL Signaling for Cancer Therapy....Pages 511-536 Back Matter....Pages 537-555 ....Pages 557-578 This book provides insight into established practices and research into apoptosis and senescence. The volume thoroughly examines novel and emerging techniques and research. Introductory chapters provide detailed overviews of topics Edited By David A. Gerwitz, Shawn E. Holt And Steven Grant.