Apoptosis in carcinogenesis and chemotherapy : apoptosis in cancer

The Purpose Of This Book Is To Provide Information On Apoptotic Processes Involved In Major Neoplastic Diseases And Their Translations Into Emerging Anti-cancer Strategies. The Book Is Divided Into 15 Chapters, Each Of Which Will Be Focused On One Particular Cancer (breast, Bladder, Cervical, Colorectal, Esophageal, Gastric, Laryngeal, Liver, Lung, Nasopharyngeal, Pancreatic, Prostate, Thyroid, Leukaemia And Cutaneous Malignant Melanoma). A Number Of Established Leaders In The Field Have Critically Summarized The Recent Discoveries Concerning Apoptosis In A Particular Cancer And Its Potential For Anti-cancer Treatment. The Book Describes How The Apoptosis Plays A Role In The Specific Carcinogen-induced Cellular And Molecular Changes During The Development Of The Cancer, And Critically Discusses How The Emerging Anti-cancer Strategy Can Be Built By The Utilization Of The Specific Carcinogen-related Apoptotic Pathway. Therefore, This Book Will Be Not Only For Laboratory-based Molecular And Cell Biologists And Biochemists In Cancer Research But Also For Clinical Oncologists And Those Working In The Pharmaceutical And Biotechnological Industries. Machine Generated Contents Note: 1.apoptotic Signaling Pathway And Resistance To Apoptosis In Breast Cancer Stem Cells / Lily Yang / Prasanthi Karna -- 2.anti-cancer Strategy Of Transitional Cell Carcinoma Of Bladder Based On Induction Of Different Types Of Programmed Cell Deaths / Jose A. Karam / Jer-tsong Hsieh -- 3.apoptosis In Carcinogenesis And Chemotherapy Of The Uterine Cervix / Sakari Hietanen -- 4.apoptosis In Colorectal Tumorigenesis And Chemotherapy / Kevin M. Sales / Shi Yu Yang / Marc C. Winslet -- 5.apoptosis In Cutaneous Melanoma / Michael B. Nicholl / Dave S. B. Hoon -- 6.apoptosis In Carcinogenesis And Chemotherapy -- Esophageal Cancer / Robert C. G. Martin / Yan Li -- 7.molecular Targets In Gastric Cancer And Apoptosis / Michael C. Garofalo / Elizabeth K. Balcer-kubiczek -- 8.apoptosis And The Tumor Microenvironment In Hematologic Malignancies / Jianguo Tao / Danielle N. Yarde -- Note Continued: 9.bcl-2 Family Members In Hepatocellular Carcinoma (hcc) -- Mechanisms And Therapeutic Potentials / Paul B. S. Lai / Shihong Ma / George G. Chen -- 10.apoptosis In The Development And Treatment Of Laryngeal Cancer: Role Of P53, Bcl-2 And Clusterin / Francisco Esteban / Rafael Funez / Maximino Redondo -- 11.cyclooxygenase 2 And Its Metabolites: Implications For Lung Cancer Therapy / Kin Chung Leung / George G. Chen -- 12.roles Of Negative And Positive Growth Regulators In Nasopharyngeal Carcinoma / Sai-ching J. Yeung / Ruiying Zhao / Huiling Yang / Mong-hong Lee -- 13.cellular Signaling Mechanisms In Pancreatic Apoptosis / Nawab Ali / R. Jean Hine / Parimal Chowdhury / Stewart Macleod -- 14.strategies To Circumvent Resistance To Apoptosis In Prostate Cancer Cells By Targeted Necrosis / Richard D. Dinnen / Daniel P. Petrylak / Robert L. Fine -- 15.carcinogenesis And Therapeutic Strategies For Thyroid Cancer / George G. Chen / Zhi-min Liu. George G. Chen, Paul B.s. Lai, Editors. Includes Bibliographical References And Index. Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes. Front Matter....Pages I-XXII Apoptotic Signaling Pathway and Resistance to Apoptosis in Breast Cancer Stem Cells....Pages 1-23 Anti-Cancer Strategy of Transitional Cell Carcinoma of Bladder Based on Induction of Different Types of Programmed Cell Deaths....Pages 25-50 Apoptosis in Carcinogenesis and Chemoherapy of the Uterine Cervix....Pages 51-73 Apoptosis in Colorectal Tumorigenesis and Chemotherapy....Pages 75-109 Apoptosis in Cutaneous Melanoma....Pages 111-125 Apoptosis in Carcinogenesis and Chemotherapy – Esophageal Cancer....Pages 127-156 Molecular Targets in Gastric Cancer and Apoptosis....Pages 157-192 Apoptosis and the Tumor Microenvironment in Hematologic Malignancies....Pages 193-218 Bcl-2 Family Members in Hepatocellular Carcinoma (HCC) – Mechanisms and Therapeutic Potentials....Pages 219-235 Apoptosis in the Development and Treatment of Laryngeal Cancer: Role of p53, Bcl-2 and Clusterin....Pages 237-249 Cyclooxygenase 2 and its Metabolites: Implications for Lung Cancer Therapy....Pages 251-272 Roles of Negative and Positive Growth Regulators in Nasopharyngeal Carcinoma....Pages 273-294 Cellular Signaling Mechanisms in Pancreatic Apoptosis....Pages 295-325 Strategies to Circumvent Resistance to Apoptosis in Prostate Cancer Cells by Targeted Necrosis....Pages 327-346 Carcinogenesis and Therapeutic Strategies for Thyroid Cancer....Pages 347-374 Back Matter....Pages 375-384 Aims to provide information on apoptotic processes involved in major neoplastic diseases and their translations into anti-cancer strategies. This book describes how the apoptosis plays a role in the specific carcinogen-induced cellular and molecular changes during the development of the cancer