Aplastic Anemia: Pathophysiology And Approaches To Therapy (haematology And Blood Transfusion Hämatologie Und Bluttransfusion)

Research on aplastic anaemia has until recently been limited to clinical description, morphology and epidemiology. New methods to culture haemopoietic cells, and advances in our knowledge of proliferation and differentiation in the haemopoietic cell system .opened a new area of scientific interest for this "prototype" of haemopoietic failure. In addition, bone marrow transplantation became not only a clinical method of treatment, but also a source of data useful for the discussion of pathophysiological models of aplastic anaemia. This situation prompted us to arrange an international con­ ference on aplastic anaemia, with particular emphasis on its patho­ physiology and the rationals of the current therapeutic approaches. This conference was held at Schloss Reisensburg from July 20-22, 1978 with the participation of both experimental and clinical scientists active in this field or in related areas of research. The proceedings of the symposion reflect the present knowledge as well as the many new questions which arose from the discussions. The editors are gratefully indebted to the participants of this meeting, to Gerlinde Trogele and all the co-workers of the Uni­ versity of Ulm engaged in preparation of this symposium and of this volume, and last not least to all sponsors who provided the financial basis for this scientific event. Front Matter....Pages I-XIII Front Matter....Pages 1-1 Introduction....Pages 3-5 Front Matter....Pages 7-7 Clinical Features of Aplastic Anaemia....Pages 9-13 Histology of Bone Marrow Failure, a Follow-up Study in Aplastic Anaemia....Pages 15-25 Epidemiology and Aetiology of Aplastic Anemia....Pages 27-37 The Role of Viral Infections in Aplastic Anemia....Pages 39-46 Aplastic Anemia Terminating in Leukemia....Pages 47-51 General Discussion....Pages 53-56 Front Matter....Pages 57-57 Aplastic Anemia — A Stem Cell Disorder?....Pages 59-61 Mechanism of Damage to the Stem Cell Population....Pages 63-72 Congenital and Induced Defects in Haemopoietic Environments, Stem Cell Proliferation and Differentiation....Pages 73-78 Independent Requirements for Early and Late Stages of Erythropoiesis....Pages 79-81 Estimation of the Pluripotential Stem Cells in Bone Marrow After Hydroxyurea....Pages 83-86 CFU-C and Colony Stimulating Activity in Human Aplastic Anemia....Pages 87-95 Granulocytic and Erythroid Progenitor Cells in Recovering Aplastic Anemia....Pages 97-102 High BPA in Aplastic Anemia, a Possible Indicator of Immune Pathogenesis....Pages 103-109 Early and Late Effects of Adjuvant Chemotherapy (Adriamycin/Cyclophosphamide) on the Human Granulopoiesis....Pages 111-122 General Discussion....Pages 123-126 Front Matter....Pages 127-127 Stimulation of Hemopoiesis in Aplastic Anemia by Hormones and Other Agents....Pages 129-137 Evolution of 352 Adult Patients Treated with Androgens: Short and Long-term Results of a Prospective Study....Pages 139-154 Insight into the Pathophysiology of Aplastic Anemia Provided Through the Results of Marrow Transplantation....Pages 155-159 Front Matter....Pages 127-127 Pathogenesis of Severe Aplastic Anemia: Inferences from Therapeutic Trials....Pages 161-165 Infusion of Fetal Liver Cells in Aplastic Anemia....Pages 167-170 Antilymphocyte Globulin Treatment in Severe Aplastic Anemia — Comparison with Bone Marrow Transplantation. Report of 60 Cases....Pages 171-179 Aplastic Anemia: Evidence of Immuno-Pathomechanisms and Successful Treatment with Absorbed ATG....Pages 181-191 The Role of Haplo-Identical Bone Marrow Transfusion in ALG Treated Patients with Severe Aplastic Anemia (SAA)....Pages 193-197 The Effect of Antithymocyte Globulin on Abnormal Lymphocyte Transformation in Patients with Aplastic Anemia....Pages 199-207 Recovery from Aplastic Anemia Following Therapy with Antithymocyte Globulin....Pages 209-217 Front Matter....Pages 219-219 Some Possible Mechanisms Leading to Autoimmune Destruction of Bone Marrow Cells....Pages 221-228 Immunologie Function in Aplastic Anemia....Pages 229-236 Serum Inhibitors of Granulocyte CFU-C in Aplastic Anaemia....Pages 237-246 Serum Inhibitors in Aplastic Anaemia....Pages 247-254 Aplastic Anemia After Bone Marrow Transplantation for Severe Combined Immunodeficiency....Pages 255-257 The Contribution of in Vitro Cultures to the Elucidation of the Pathogenesis of Aplastic Anaemia....Pages 259-264 Interpretations of Culture Data in Aplastic Anemia: Evidence for a Suppressor Cell Involvement....Pages 265-271 Co-culture Studies in Transfused and Untransfused Patients with Aplastic Anemia....Pages 273-276 General Discussion....Pages 277-279 Front Matter....Pages 281-281 Final Discussion....Pages 283-288 Front Matter....Pages 289-289 Summing-up....Pages 291-292 Back Matter....Pages 293-294