Anxiety and Anxiolytic Drugs (Handbook of Experimental Pharmacology, 169)

The present volume gives a comprehensive overview on the current state of basic and clinical research on **Anxiety and Anxiolytic Drugs . Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment. In parallel, new drug targets have been generated and the first clinical studies with new compounds have been started. In 20 chapters written by numerous experts in the field comprehensive information on all relevant topics is provided.** Learning And Memory / C. T. Wotjak -- Animal Models Of Anxiety / F. Ohl -- Genetic Alterations Of The Murine Serotonergic Gene Pathway : The Neurodevelopmental Basis Of Anxiety / K. P. Lesch -- Mutagenesis And Knockout Models : Hypothalamic-pituitary-adrenocortical System / M. E. Keck And M. B. Muller -- Mutagenesis And Knockout Models : Nk1 And Substance P / A. Bilkei-gorzo And A. Zimmer -- Genetic Epidemiology Of Anxiety Disorders / K. R. Merikangas And N. C. P. Low -- Interactions Between Corticotropin-releasing Hormone And Serotonin : Implications For The Aetiology And Treatment Of Anxiety Disorders / A. C. E. Linthorst -- Anxiety Disorders : Noradrenergic Neurotransmission / A. Neumeister, R. J. Daher And D. S. Charney -- Pathophysiology And Pharmacology Of Gaba[subscript A] Receptors / H. Mohler, J.-m. Fritschy, K. Vogt, F. Crestani And U. Rudolph -- Excitatory Amino Acid Neurotransmission / C. G. Parsons, W. Danysz And W. Zieglgansberger -- Neurobiology And Treatment Of Anxiety : Signal Transduction And Neural Plasticity / C. H. Duman And R. S. Duman -- Neuropeptides In Anxiety Modulation / R. Landgraf -- Neuroendocrine Aspects Of Ptsd / R. Yehuda -- Anxiety Disorders : Clinical Presentation And Epidemiology / R. Lieb -- Transcultural Issues / M. T. Lin And K.-m. Lin -- Challenge Studies In Anxiety Disorders / M. E. Keck And A. Strohle -- Pharmacotherapy Of Anxiety / J. R. Nash And D. J. Nutt -- New Pharmacological Treatment Approaches For Anxiety Disorders / A. Strohle -- Pharmacogenomics / E. B. Binder And F. Holsboer -- Pharmacoproteomics / C. W. Turck. Contributors, A. Bilkei-gorzo ... [et Al.] ; Editors, Florian Holsboer And Andreas Ströhle. Includes Bibliographical References And Index. Learning and Memory....Pages 1-34 Animal Models of Anxiety....Pages 35-69 Genetic Alterations of the Murine Serotonergic Gene Pathway: The Neurodevelopmental Basis of Anxiety....Pages 71-112 Mutagenesis and Knockout Models: Hypothalamic-Pituitary-Adrenocortical System....Pages 113-141 Mutagenesis and Knockout Models: NK1 and Substance P....Pages 143-162 Genetic Epidemiology of Anxiety Disorders....Pages 163-179 Interactions Between Corticotropin-Releasing Hormone and Serotonin: Implications for the Aetiology and Treatment of Anxiety Disorders....Pages 181-204 Anxiety Disorders: Noradrenergic Neurotransmission....Pages 205-223 Pathophysiology and Pharmacology of GABA A Receptors....Pages 225-247 Excitatory Amino Acid Neurotransmission....Pages 249-303 Neurobiology and Treatment of Anxiety: Signal Transduction and Neural Plasticity....Pages 305-334 Neuropeptides in Anxiety Modulation....Pages 335-369 Neuroendocrine Aspects of PTSD....Pages 371-403 Anxiety Disorders: Clinical Presentation and Epidemiology....Pages 405-432 Transcultural Issues....Pages 433-447 Challenge Studies in Anxiety Disorders....Pages 449-468 Pharmacotherapy of Anxiety....Pages 469-501 New Pharmacological Treatment Approaches for Anxiety Disorders....Pages 503-526 Pharmacogenomics....Pages 527-546 Pharmacoproteomics....Pages 547-560