Anxiety and Anxiolytic Drugs (Handbook of Experimental Pharmacology, 169)

The present volume gives a comprehensive overview on the current state of basic and clinical research on **Anxiety and Anxiolytic Drugs . Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment. In parallel, new drug targets have been generated and the first clinical studies with new compounds have been started. In 20 chapters written by numerous experts in the field comprehensive information on all relevant topics is provided.** Learning And Memory / C. T. Wotjak -- Animal Models Of Anxiety / F. Ohl -- Genetic Alterations Of The Murine Serotonergic Gene Pathway : The Neurodevelopmental Basis Of Anxiety / K. P. Lesch -- Mutagenesis And Knockout Models : Hypothalamic-pituitary-adrenocortical System / M. E. Keck And M. B. Muller -- Mutagenesis And Knockout Models : Nk1 And Substance P / A. Bilkei-gorzo And A. Zimmer -- Genetic Epidemiology Of Anxiety Disorders / K. R. Merikangas And N. C. P. Low -- Interactions Between Corticotropin-releasing Hormone And Serotonin : Implications For The Aetiology And Treatment Of Anxiety Disorders / A. C. E. Linthorst -- Anxiety Disorders : Noradrenergic Neurotransmission / A. Neumeister, R. J. Daher And D. S. Charney -- Pathophysiology And Pharmacology Of Gaba[subscript A] Receptors / H. Mohler, J.-m. Fritschy, K. Vogt, F. Crestani And U. Rudolph -- Excitatory Amino Acid Neurotransmission / C. G. Parsons, W. Danysz And W. Zieglgansberger -- Neurobiology And Treatment Of Anxiety : Signal Transduction And Neural Plasticity / C. H. Duman And R. S. Duman -- Neuropeptides In Anxiety Modulation / R. Landgraf -- Neuroendocrine Aspects Of Ptsd / R. Yehuda -- Anxiety Disorders : Clinical Presentation And Epidemiology / R. Lieb -- Transcultural Issues / M. T. Lin And K.-m. Lin -- Challenge Studies In Anxiety Disorders / M. E. Keck And A. Strohle -- Pharmacotherapy Of Anxiety / J. R. Nash And D. J. Nutt -- New Pharmacological Treatment Approaches For Anxiety Disorders / A. Strohle -- Pharmacogenomics / E. B. Binder And F. Holsboer -- Pharmacoproteomics / C. W. Turck. Contributors, A. Bilkei-gorzo ... [et Al.] ; Editors, Florian Holsboer And Andreas Ströhle. Includes Bibliographical References And Index.