Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance, 2nd Edition

Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance by Gerald E. McDonnell is a detailed and accessible presentation of microbial control methods. Each major category, such as physical disinfection methods, is given a chapter, in which theory, spectrum of activity, advantages, disadvantages, and modes of action of the methods are thoroughly and clearly presented. Sufficient background on the life cycles and general anatomy of microorganisms is provided so that the reader who is new to microbiology will better appreciate how physical and chemical biocides work their magic on microbes. Topics covered include: Evaluating the efficacy of chemical antiseptics and disinfectants, and of physical methods of microbial control and sterlization; how to choose the proper biocidal product and process for specific applications; classic physical and chemical disinfection methods, such as heat, cold, non-ionizing radiation, acids, oxidizing agents, and metals; chemical sterlization methods that use ethylene oxide, formaldehyde, or a variety of other oxidizing agents; Modes of action of biocides in controlling microbial growth and disrupting microbial physiology; Mechanisms that microorganisms use to resist the effects of biocides. The second edition of Antisepsis, Disinfection, and Sterlization: Types, action, and resistance is well suited as a textbook and is outstanding as a reference book for facilities managers and application engineers in manufacturing plants, hospitals, and food production facilities. It is also essential for public health officials, health care professionals, and infection control practitioners. -- from back cover. Read more... The theory and practice of controlling and eliminating microorganisms Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance , by Gerald E. McDonnell, is a detailed and accessible presentation of the current methods of microbial control. Each major category, such as physical disinfection methods, is given a chapter, in which theory, spectrum of activity, advantages, disadvantages, and modes of action of the methods are thoroughly and clearly presented. Sufficient background on the life cycles and general anatomy of microorganisms is provided so that the reader who is new to microbiology will better appreciate how physical and chemical biocides work their magic on microbes. Other topics in the book include: Evaluating the efficacy of chemical antiseptics and disinfectants, and of physical methods of microbial control and sterilization. Understanding how to choose the proper biocidal product and process for specific applications. Classic physical and chemical disinfection methods, such as heat, cold, non-ionizing radiation, acids, oxidizing agents, and metals. Newer chemical disinfectants, including, isothiazolones, micro-and nano-particles, and bacteriophages as control agents. Antisepsis of skin and wounds and the biocides that can be used as antiseptics. Classic methods of physical sterilization, such as, moist heat and dry heat sterilization, ionizing radiation, and filtration, along with newer methods, including, the use of plasma or pulsed light. Chemical sterilization methods that use ethylene oxide, formaldehyde, or a variety of other oxidizing agents. A detailed look at the modes of action of biocides in controlling microbial growth and disrupting microbial physiology. Mechanisms that microorganisms use to resist the effects of biocides. The second edition of Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance is well suited as a textbook and is outstanding as a reference book for facilities managers and application engineers in manufacturing plants, hospitals, and food production facilities. It is also essential for public health officials, healthcare professionals, and infection control practitioners. Hardcover, 432 pages, full-color illustrations, index. Chapter I: Introduction -- General introduction -- Definitions -- General microbiology -- General considerations -- Disinfection versus sterilization -- Choosing a process or product -- Guidelines and standards -- Formulation effects -- Process effects -- The importance of surface cleaning -- Water quality -- Chapter 2: Physical disinfection -- Introduction -- Heat -- Cold temperatures -- Radiation -- Filtration -- Chapter 3: Chemical disinfection -- Introduction -- Acids and acid derivatives -- Alkalis or bases -- Aldehydes -- Alcohols -- Anilides -- Antimicrobial dyes -- Biguanides -- Diamidines -- Essential oils and plant extracts -- Halogens and halogen-releasing agents -- Metals -- Peroxygens and other forms of oxygen -- Phenolics -- Antiseptic phenolics -- Quaternary ammonium compounds and surfactants -- Other miscellaneous biocides or applications -- Chapter 4: Antiseptics and antisepsis -- Introduction -- Some definitions specific to antisepsis -- Structure of skin -- Skin microbiology -- Antiseptic applications -- Biocides used as antiseptics -- Chapter 5: Physical sterilization -- Introduction -- Moist heat sterilization -- Dry heat sterilization -- Radiation sterilization -- Filtration -- Other physical sterilization methods -- Chapter 6: Chemical sterilization -- Introduction -- Epoxides -- Low temperature steam-formaldehyde -- High temperature formaldehyde-alcohol -- Hydrogen peroxide -- Other oxidizing agent-based processes -- Chapter 7: Mechanisms of action -- Introduction -- Anti-infectives -- Macromolecular structure -- General mechanisms of action -- Chapter 8: Mechanisms of microbial resistance -- Introduction -- Biocide/microorganism interaction -- Intrinsic bacterial resistance mechanisms -- Intrinsic resistance of mycobacteria -- Intrinsic resistance of other Gram-positive bacteria -- Acquired bacterial resistance mechanisms -- Mechanisms of viral resistance -- Mechanisms of prion resistance -- Mechanisms of fungal resistance -- Mechanisms of resistance in other eukaryotic microorganisms. Provides descriptive background material covering the applications and various chemical and physical processes used for microbial control. An array of biocides is described, and the variables affecting their safe and effective use are detailed. The advantages, disadvantages, limitations, and correct applications of biocides and biocidal processes are discussed as well. The mechanisms of biocidal action on microorganisms are investigated, including an examination of the less-studied intrinsic and acquired mechanisms of resistance in viruses, prions, protozoa, and fungi. Further considerations are given to the mechanisms on intrinsic and acquired resistance to biocides and biocidal processes, including cross-resistance to antibiotics in bacteria and novel mechanisms in extremophiles