Antimicrobial Susceptibility Testing: Critical Issues for the 90s (Advances in Experimental Medicine and Biology, 349)

The papers assembled in this collection comprise a majority of the oral presentations as well as several poster presentations given at the 22nd Annual Symposium arranged by the Bastern Pennsylvania Branch of the American Society for MicrobioloS)'. The symposium would not be possible without the generous support of the many sponsors (see sponsor list) or without the concerted effort of a11 the Committee members. This Symposium series has evolved into an annual Bastern Pennsylvania Branch ASM event that attracts participants from a wide geographie area. It should be noted that one of the hallmarks of these symposia involves interaction between the presenters and those in attendance. Several authors have altered their by the participants. Therefore, the manuscript that manuscripts based on comments fo11ows should be viewed as a group effort of both the participants and presenters. J ames Poupard Lori Walsh Bruee Kleger ix CONTENTS 1 Introduction 1: CURRENT METHODS The Evolution of Antimicrobial Susceptibility Testing Methods . . . . . . . . . . . . . . . 3 James A. Poupard, Stephen F. Rittenhouse, and Lori R. Walsh Antimicrobial Susceptibility Tests: Testing Methods and Interpretive Problems. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Patrick R. Murray Clinician Utilization of Rapid Antibiotic Susceptibility Data: A Prospective Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Franklin P. Koontz SESSION 2: CONTEMPORARY ISSUES IN SUSCEPTIBILITY TESTING When We Should Be Testing, How Often and What to Report . . . . . . . . . . . . . . . 35 Raymond C. Bartlett Areas of Recent Emphasis of the National Committee for Clinical Laboratory Standards Subcommittee on Antimicrobial Susceptibility Testing . . . . . . . . . . . . . . . . . . . . . . . 61 James H. Jorgensen Non-Traditional Approaches for Quality Control of Antimicrobial Susceptibility Tests . . . . . . . . . . . . . . . . . . . . . . . . . Front Matter....Pages i-xii Introduction....Pages 1-2 The Evolution of Antimicrobial Susceptibility Testing Methods....Pages 3-14 Antimicrobial Susceptibility Tests: Testing Methods and Interpretive Problems....Pages 15-25 Clinician Utilization of Rapid Antibiotic Susceptibility Data: A Prospective Study....Pages 27-34 When We should be Testing, How often and what to Report....Pages 35-60 Areas of Recent Emphasis of the National Committee for Clinical Laboratory Standards Subcommittee on Antimicrobial Susceptibility Testing....Pages 61-65 Non-Traditional Approaches for Quality Control of Antimicrobial Susceptibility Tests....Pages 67-85 Applications of Medical Informatics in Antibiotic Therapy....Pages 87-96 Established Antimicrobial Susceptibility Testing Methods with a New Twist — Points to Consider and a Glimpse of the Future....Pages 97-105 Measures of Susceptibility from a Spiral Gradient of Drug Concentrations....Pages 107-120 Commercialization of Nucleic Acid Probe Technology: Current Status....Pages 121-129 Is One Laboratory in Town Enough?....Pages 131-134 The FDA Review Criteria for Assessment of Antimicrobial Susceptibility Devices — Too Much or Not Enough Regulation?....Pages 135-143 The Evolution of Clinical Laboratory Regulation — A Primer for Universal Health Care....Pages 145-152 Current Issues in Antimicrobial Susceptibility Testing....Pages 153-156 The Use of In-Vitro Kinetic Models in the Evaluation of β-Lactam/β-Lactamase Inhibitor Combinations....Pages 157-162 Prevalence of Ticarcillin/Clavulanic Acid-Resistant Enterobacteriacaeae in Nine Separate Medical Centers During the Years 1983, 1989, and 1991....Pages 163-176 Correlation of Minimum Inhibitory Concentration Results between the Vitek System and the Biomic System....Pages 177-186 Back Matter....Pages 187-191