Antidepressants Therapy And Risk Of Suicide Among Patients With Major Depressive Disorders (psychiatry - Theory, Applications And Treatments)

Most cases of suicide (81%–95%) in the general population involve psychiatric illnesses, nearly half of which (48.5%) are mood disorders. Internationally, the overall average suicide rate has been rising gradually over the past half-century, with increases reported in about half of nations, mainly among men, and moderate decreases found in another half, including in Northern Europe and North America. This book reviews whether the use of antidepressants is associated with benefits in terms of completed or attempted suicide, whether the increasing use of SSRIs is associated with benefits in terms of decreased rates of suicide with the aim of generating evidence-based suggestions for clinicians. Introduction : the complex challenge of suicide Antidepressants and suicidal risk The relationship between antidepressants and suicide as reported in ecological studies The relationship between antidepressants and suicide as reported in cohort and case-control studies The relationship between antidepressants and suicide as reported in randomized controlled trials (RCTS) The relationship between antidepressants and suicide in different countries Possible explanations for the lack of effect on suicidal risk during antidepressant treatment and clinical implications Adverse effect of antidepressants and suicide mortality.