Antidepressants: From Biogenic Amines to New Mechanisms of Action (Handbook of Experimental Pharmacology, 250)

This volume reviews the known neurobiology of depression and combines classic data on antidepressant treatments with modern theory on the physiology of depression. It also discusses novel mechanism of action drugs, and outlines the most up to date evidence regarding the treatment of depression Front Matter ....Pages i-xii Impact, Diagnosis, Phenomenology, and Biology (William Coryell)....Pages 3-33 Tricyclic Antidepressants and Monoamine Oxidase Inhibitors: Are They Too Old for a New Look? (Ravikumar Chockalingam, Britt M. Gott, Charles R. Conway)....Pages 37-48 Clinical Implications of the STAR*D Trial (A. John Rush, Shailesh (Bobby) Jain)....Pages 51-99 Pharmacogenomics and Biomarkers of Depression (Manish K. Jha, Madhukar H. Trivedi)....Pages 101-113 Therapeutic Drug Monitoring of Antidepressants (Najla Fiaturi, David J. Greenblatt)....Pages 115-133 Selective Serotonin Reuptake Inhibitors (Dee Lochmann, Tara Richardson)....Pages 135-144 Serotonin and Norepinephrine Reuptake Inhibitors (Richard C. Shelton)....Pages 145-180 Neurostimulation Therapies (Nicholas T. Trapp, Willa Xiong, Charles R. Conway)....Pages 181-224 Current Role of Herbal and Natural Preparations (David Mischoulon, Mark Hyman Rapaport)....Pages 225-252 Role of Inflammation in Depression and Treatment Implications (Jennifer C. Felger)....Pages 255-286 NMDA Antagonists for Treatment-Resistant Depression (Nuri B. Farber)....Pages 287-305 Drug Development in Psychiatry: The Long and Winding Road from Chance Discovery to Rational Development (Sheldon H. Preskorn)....Pages 307-324 Other Antidepressants (T. E. Schwasinger-Schmidt, M. Macaluso)....Pages 325-355 Use of Antidepressants in Patients with Co-occurring Depression and Substance Use Disorders (Theadia L. Carey)....Pages 359-370 Treatment of Depression in Women (Christina Bourne, Laura Kenkel)....Pages 371-387 Management of Late-Life Depression (J. Craig Nelson)....Pages 389-413 The Use of Antidepressants in Bipolar Depression (John L. Beyer)....Pages 415-442