درمان ضدانعقادی: راهنمای بالینی، ویرایش دوم

Although highly effective in preventing thromboembolic events, the safe management of anticoagulant therapy continues to be a major challenge, requiring constant monitoring and coordinated models of patient-centered care. Anticoagulation Therapy: A Clinical Practice Guide, Second Edition, helps take the guesswork out of managing these therapies and provides essential recommendations. This revised and expanded edition includes: Extensive new information on the direct oral anticoagulants (DOACs) Expanded information on anticoagulant reversal and expanded use of prothrombin complex concentrates New chapters on the use of anticoagulants in special patient populations, the use of anticoagulants in patients with mechanical devices, anticoagulation care delivery standards, regulatory issues, and more Four new appendices on the effect of DOACs on chemotherapy, nutritional influences, types of central nervous system hemorrhage, and use of anticoagulation in patients with coagulopathies Cover Title page Copyright Dedication Contents Contributing Editors Contributors Preface Acknowledgments Abbreviations Part I. Anticoagulation Medication Management Ch 1. Introduction to Anticoagulation Management Ch 2. Warfarin Ch 3. Unfractionated Heparin Ch 4. Low Molecular Weight Heparin and Fondaparinux Ch 5. Parenteral Direct Thrombin Inhibitors Ch 6. Thrombolytic Considerations When Used with Anticoagulants Ch 7. Direct Oral Anticoagulants Ch 8. Anticoagulation Reversal: Part I—Pharmacology of Agents Used for Reversal Ch 9. Anticoagulation Reversal: Part II—Clinical Application Ch 10. Transitions in Care—Periprocedural Bridging and Transitions Between Agents Ch 11. Considerations in Special Populations Part II. Conditions Requiring Anticoagulation Therapy Ch 12. Venous Thromboembolism Prevention Ch 13. Venous Thromboembolism Treatment Ch 14. Atrial Fibrillation Ch 15. Acute Coronary Syndromes Ch 16. Prosthetic Heart Valves Ch 17. Mechanical Circulatory Support Devices Ch 18. Heparin-Induced Thrombocytopenia Ch 19. Pregnancy Ch 20. Pediatrics Part III. Practical Measuring, Monitoring, and Coagulation Laboratory Insights Ch 21. Coagulation Laboratory Considerations Ch 22. Thrombophilias Part IV. Essentials for Practice Success Ch 23. Models and Standards of Anticoagulation Care Delivery Ch 24. Regulatory and Practice Resources Appendixes Appendix A. Coagulation Cascade Appendix B. Agents Implicated in Drug-Induced Thromboembolic Diseases Appendix C. Nutrition Influence on Anticoagulation Appendix D. Anticoagulants in Management of Ischemic Stroke or Transient Ischemic Attacks Appendix E. Citrate Anticoagulation Appendix F. Examples of Available Bleeding Definitions Appendix G. Types of CNS Hemorrhage Appendix H. Disseminated Intravascular Coagulation Appendix I. Nondrug Causes of Thrombocytopenia Appendix J. Drug-Related Causes of Thrombocytopenia Appendix K. Examples of Transfusion-Related Reactions Appendix L. Considerations for Transitioning from aPTT to Anti-Xa to Manage Heparin Therapy Appendix M. PIONEER AF-PCI Appendix N. Betrixaban APEX Trial Index Although highly effective in preventing thromboembolic events, the safe management of anticoagulant therapy continues to be a major challenge, requiring constant monitoring and coordinated models of patient-centered care. This volume helps take the guesswork out of managing these therapies and provides essential recommendations.