Anticancer Plants : Mechanisms and Molecular Interactions. Volume 4 / edited by Mohd Sayeed Akhtar, Mallappa Kumara Swamy

This book summarizes the application of plant derived anticancer compounds as chemopreventives to treat several cancer types, focusing on the molecular mechanisms of action of phytocompounds and providing an overview of the basic processes at the cellular and molecular level that are involved in the progression of the cancer and can be employed in targeted preventive therapies. In addition, it highlights the development of novel anticancer drugs from plant sources using bioinformatics approaches. The compiled chapter data aids readers understanding of issues related to bioavailability, toxic effects and mechanisms of action of phytocompounds, and helps them identify the leads and utilize them against various cancer types effectively. Furthermore, it promotes the use of bioinformatics tools in medicinal plants to expedite their use in plant breeding programs to develop molecular markers to distinguish disease subtypes and predicting mutation, which in turn improves cancer diagnosis and prognosis, and to develop new lead compounds computationally. The book provides scientific verifications of plant compounds mechanisms of action against various cancers and offers useful information for students, teachers, and healthcare professionals involved in drug discovery, and clinical and therapeutic research. Front Matter ....Pages i-xiv Omics: A Holistic Approach in Cancer Treatment (Madhumati Bora, Pratibha Parihar)....Pages 1-26 Plant miRNAs and Phytomolecules As Anticancer Therapeutics (Nikita Shukla, Virendra Shukla, Sangeeta Saxena)....Pages 27-41 Potential of Herbal Medicines in Colorectal Carcinoma and Their Mechanism of Action (Navina Panneerselvan, Rajeswari Ravindran, Palanisamy Arulselvan, Ravindran Jaganathan)....Pages 43-97 Elucidation of Mechanisms of Anticancer Plant Compounds Against the Tumor Cells (Radhakrishnan Narayanaswamy, Mallappa Kumara Swamy)....Pages 99-130 Computational Approach Towards Exploring Interaction of Target Protein-Phytocompounds in Drug Development for Breast Cancer (Asita Elengoe, Salehhuddin Hamdan)....Pages 131-141 Anticancer Potential of Andrographolide, a Diterpenoid Lactone from Andrographis paniculata: A Nature’s Treasure for Chemoprevention and Therapeutics (Imran Khan, Mohd Aslam Yusuf, Irfan Ahmad Ansari, Mohd Sayeed Akhtar)....Pages 143-163 Anticancer Activity of Herbal Medicine: Mechanism of Action (Nand Kumar Singh, Alok Kumar Yadav, Preeti Sirohi, Manjoo Rani, Saurabh Saraswat, Manish Pratap Singh et al.)....Pages 165-196 Metabolomic Study of Chemo-preventive Phytochemicals and Their Therapeutic Prospects (Nibir Ranjan Parasar, Channakeshavaiah Chikkaputtaiah, Mohan Lal, Mohd Sayeed Akhtar)....Pages 197-207 CADD Studies Applied to Secondary Metabolites in the Anticancer Drug Research (Luciana Scotti, Nagendra Sastry Yarla, Francisco J. B. Mendonça Filho, José M. Barbosa Filho, Marcelo S. da Silva, Josean F. Tavares et al.)....Pages 209-225 Anticancerous Plant Compounds Affecting the Power House of Cancerous Cells: A Possible Herbal Mitocan (Shalini Mani, Nancy Taneja, Sweekriti Jain, Manisha Singh)....Pages 227-258 Phytoestrogens as a Natural Source for the Possible Colon Cancer Treatment (Suresh Challa, Rajanna Ajumeera, Naresh Venna)....Pages 259-281 Bioinformatics Approaches for Genomics and Post Genomics Applications of Anticancer Plants (Avni Mehta, Yasha Hasija)....Pages 283-317 Fruits of Rosaceae Family as a Source of Anticancer Compounds and Molecular Innovations (Muhammad Sameeullah, Muttalip Gündoğdu, İhsan Canan, Turan Karadeniz, Muhammad Aasim, Khalid Mahmood Khawar)....Pages 319-336 Mechanism of Action of Anticancer Herbal Medicines (Mohd Gulfishan, Muhammad Afzal, Imran Kazmi, Anwarulabedin Mohsin Quazi, Tariq Ahmad Bhat, Ajmat Jahan)....Pages 337-360