Antibodies in Cytokines : The Concerted Action on the Antigenicity of RDNA Derived Pharmaceuticals

This book, written by leading authors in the field, is the first to deal with all aspects of cytokine antibodies, from test methodology and standardization to biological consequences and functions. It encompasses antibodies induced by cytokines used therapeutically and antiviral antibodies. To understand the biology, the effects of cytokine antibodies in experimental animal models and patients are also discussed. The book is intended for researchers of cytokine biology, pharmaceutical companies developing cytokines and cytokine antibodies as therapies, and clinicians interested in modulating the immune system as therapy. Front Matter....Pages i-iii The Incidence and Clinical Significance of Antibodies to Interferon-a in Patients with Solid Tumors....Pages 1-5 Interferon antibodies in patients with infectious diseases....Pages 7-14 Treatment-induced antibodies to interleukin-2....Pages 15-24 Natural antibodies to IL-2....Pages 25-28 Natural antibodies to interferon-gamma....Pages 29-37 Anti-cytokine autoantibodies: Epiphenomenon or critical modulators of cytokine action....Pages 39-48 Potential therapeutic use of antibodies directed towards HuIFN-γ....Pages 49-57 Structure-activity of type I interferons....Pages 59-86 Measurement of cytokine antibodies. Test development....Pages 87-92 The Expression of Potency of Neutralizing Antibodies for Interferons and other Cytokines....Pages 93-98