Antibiotics Vol. 3. Mechanism of action of antimicrobial and antitumor agents

This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since the appearance of Volume I, also dealing with Mechanism of Action, tremendous strides have been made in the depth and breadth of our knowledge of molecular biology, microbial chemistry and molecular pharmacology and of their direct application to studies on the mode of action of drugs. The field of molecular biology itself was in its relative infancy during the preceding decade and the unique role played by many anti­ biotics in the development of our understanding of nucleic acid synthesis and function and its relationship to protein synthesis and cell physiology has led rapidly to a very precise, understanding of how many of these same antibiotics inhibit susceptible cells. Front Matter....Pages I-XII Front Matter....Pages 1-1 Anthramycin....Pages 3-11 3′-Amino-3′-Deoxyadenosine....Pages 12-20 Bleomycin....Pages 21-33 Berenil: A Trypanocide with Selective Activity against Extranuclear DNA....Pages 34-47 Camptothecin....Pages 48-57 Chloroquine (Resochin)....Pages 58-78 Distamycin A and Netropsin....Pages 79-100 Daunomycin (Daunorubicin) and Adriamycin and Structural Analogues: Biological Activity and Mechanism of Action....Pages 101-128 Edeines....Pages 129-140 Ethidium and Propidium....Pages 141-165 Kanchanomycin....Pages 166-173 Nalidixic Acid—Mode of Action....Pages 174-196 Olivomycin, Chromomycin, and Mithramycin....Pages 197-202 Quinacrine and Other Acridines....Pages 203-233 Quinoxaline Antibiotics....Pages 234-251 Rifamycins and Other Ansamycins....Pages 252-268 Sibiromycin....Pages 269-273 Thiaxanthenones: Miracil D and Hycanthone....Pages 274-302 Addendum....Pages 302-303 Trimethoprim and Pyrimethamine....Pages 304-320 Front Matter....Pages 321-321 Althiomycin....Pages 323-326 Aurintricarboxylic Acid a Non-Antibiotic Organic Molecule that Inhibits Protein Synthesis....Pages 327-339 Aminoglycoside Antibiotics....Pages 340-364 Borrelidin....Pages 365-369 Chloramphenicol....Pages 370-395 The Erythromycins....Pages 396-419 Emetine and Related Alkaloids....Pages 420-435 Fusidic Acid....Pages 436-447 Gougerotin....Pages 448-458 The Macrolide Antibiotics....Pages 459-479 Micrococcin and Micrococcin P....Pages 480-486 Mikamycin....Pages 487-497 Pactamycin....Pages 498-515 Primaquine....Pages 516-520 The Streptogramin Family of Antibiotics....Pages 521-534 Streptomycin, Dihydrostreptomycin, and the Gentamicins....Pages 535-550 The Thiostrepton Group of Antibiotics....Pages 551-573 Front Matter....Pages 575-575 Berberine....Pages 577-584 Boromycin....Pages 585-587 Colicins 1972....Pages 588-605 Front Matter....Pages 575-575 Griseofulvin....Pages 606-613 Irehdiamine and Malouetine....Pages 614-622 Isonicotinic Acid Hydrazide....Pages 623-652 Sideromycins....Pages 653-667 Sulfonamides and Sulfones....Pages 668-698 Suramin....Pages 699-703 Vancomycin....Pages 704-718 Back Matter....Pages 719-744