Antiandrogen-estrogen Therapy For Signs Of Androgenization (new Developments In Biosciences ; 3)

including those of translation into foreign languages. No part of this book may be reproduced in any form -by fotoprint, microfilm, or any other means -nor translated into a machine language without written permission from the publisher. Typesetting, Printing and Binding: Mohndruck, Gütersloh -Cover design: Rudolf Hübler. -Printed in Germany. The quotation of registered names, trade names, trade marks, etc. in this copy does not imply, even in the absence of a specific statement that such names are exempt from laws and regulations protecting trade marks, etc. and therefore free for general use. going to be dealt with here, but there is a report of Professor Falsetti on the treatment of micropolycystic ovaries where these issues might appear to be relevant. I think I have amply used up the time allotted to me for this introduction, for this welcome, a welcome I am glad to repeat and which I extend in the hope that this meeting-and I am certain my hope will be realized-prove profitable, useful, important to all of us. Thank you. Contents ## IV Special aspects Clinical assessment of two antiandrogen treatments, cyproterone acetate combined with ethinyl estradiol and spironolactone in hirsutism R. Rubens, A. Vermeulen Treatment of severe androgenization symptoms with Diane® and intramuscularly applied cyproterone acetate (Androcur® Depot Welcome address Contents Introduction Antiandrogen therapy for signs of androgenization: an overview I. Pharmacology and physiology Pharmacological aspects of cyproterone acetate Pharmacokinetics of cyproterone acetate and ethinyl estradiol in smoking and non-smoking women during treatment with Diane-35 Ovulation inhibitory effect of SH B 209 AE (Diane-35)—a new antiandrogen-estrogen combination A study to investigate the maintenance of ovulation inhibition when patients switch over from Diane to Diane-35 Effect of a new antiandrogen-estrogen sub-fifty combination on the endometrium II. Polycystic ovary syndrome Endocrinological and clinical findings on the therapy with Diane-35 in polycystic ovary syndrome Discussion III. Effects on the haemostatic system Longitudinal study on the effects of a cyproterone acetate and ethinyl estradiol combination on haemostasis Haemorheological effects of Diane-35 and Microgynon®—Preliminary results of a double blind study Antiandrogen treatment in women with acne: a controlled trial IV Special aspects Clinical assessment of two antiandrogen treatments, cyproterone acetate combined with ethinyl estradiol and spironolactone in hirsutism Treatment of severe androgenization symptoms with Diane and intramuscularly applied cyproterone acetate (Androcur Depot) One-year experience with a new oral contraceptive using natural estradiol and cyproterone acetate Discussion V. Metabolic and clinical aspects Clinical and metabolic effects of a new estrogenantiandrogen low dose combination Effects of cyproterone acetate on serum lipoproteins when administered alone and in combination with ethinyl estradiol Clinical, metabolic and endocrine effects of long term use of a cyproterone acetate and ethinyl estradiol combination in hyperandrogenized women Cyproterone acetate versus levonorgestrel combined with ethinyl estradiol in the treatment of acne : results of a multi-center study Comparison of Diane-35 with Neo-Eunomin from the dermatological viewpoint A double blind comparative study of tetracycline and Diane, alone and in combination in the treatment of acne The comparative efficacy and safety of Diane- 35 versus Diane-50 in the treatment of moderate to severe acne and seborrhea: preliminary results Results of an extended open phase m study with Diane-35 Discussion Closing remarks List of first-mentioned contributors

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