Anti-Inflammatory Agents Part II Vol. 13, Pt. 2: Chemistry and Pharmacology

Medicinal Chemistry: A Series of Monographs, Volume 13–I explores the development in the treatment of some severely debilitating chronic inflammatory diseases, including arthritis, gout, rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, psoriasis, conjunctivitis, episcleritis, and uveitis. This volume examines the anti-inflammatory drugs used to alter the inflammatory response in diseases of unknown cause. This book is comprised of two parts encompassing 11 chapters. Part I discusses the factors that cause the inflammation and explores the interaction of these causative agents with those therapies found to be clinically effective. This text also presents an illustrative classification of some debilitating inflammatory conditions and the available therapy. Part II explores the nonsteroidal anti-inflammatory agents that are peripheral analgesics and anti-pyretic. Other chapters review colchicine and allopurinol as anti-inflammatory drugs for gout. Finally, this volume ends with a discussion on the anti-inflammatory activity of some proteolytic enzymes of vegetable, animal, fungal, and bacterial origin. Physicians, chemists, and experimental biologists will find this book extremely useful. Content: MEDICINAL CHEMISTRY: A Series of Monographs , Page ii Front Matter , Page iii Copyright , Page iv Dedication , Page v List of Contributors , Pages xi-xii Preface , Pages xiii-xiv , ROBERT A. SCHERRER, MICHAEL W. WHITEHOUSE Contents of Volume II , Pages xv-xvi Introduction , Pages xvii-xx , ROBERT A. SCHERRER, MICHAEL W. WHITEHOUSE Selected Reviews Dealing with Antiinflammatory Drugs , Pages xxi-xxii Chapter 1 - Some Inflammatory Diseases in Man and Their Current Therapy , Pages 3-26 , HAROLD E. PAULUS Chapter 2 - Introduction to the Chemistry of Antiinflammatory and Antiarthritic Agents , Pages 29-43 , ROBERT A. SCHERRER Chapter 3 - Aryl- and Heteroarylcarboxylic Acids , Pages 45-89 , ROBERT A. SCHERRER Chapter 4 - Aryl- and Heteroarylalkanoic Acids and Related Compounds , Pages 91-127 , PETER F. JUBY Chapter 5 - Enolic Acids with Antiinflammatory Activity , Pages 129-157 , JOSEPH G. LOMBARDINO Chapter 6 - Sulfonamides with Antiinflammatory Activity , Pages 159-177 , GEORGE G.I. MOORE Chapter 7 - Nonacidic Antiarthritic Agents and the Search for New Classes of Agents , Pages 179-207 , T.Y. SHEN Chapter 8 - Design and Laboratory Evaluation of Gold Compounds as Antiinflammatory Agents , Pages 209-244 , DONALD T. WALZ, MICHAEL J. DIMARTINO, BLAINE M. SUTTON Chapter 9 - Antiinflammatory Steroids , Pages 245-294 , THOMAS L. POPPER, ARTHUR S. WATNICK Chapter 10 - Colchicine and Allopurinol , Pages 295-361 , THOMAS J. FITZGERALD Chapter 11 - Antiinflammatory Proteins and Peptides , Pages 363-384 , J.D. FISHER Author Index , Pages 385-410 Subject Index , Pages 411-417 Medicinal Chemistry: A Series of Monographs, Volume 13–II presents the context of inflammation and the therapeutic interventions in debilitating chronic inflammatory diseases. This book discusses the progress of therapeutics in the field of medicine with less cost but with the same degree of benefit. Comprised of 10 chapters, this volume begins with a discussion on the pathophysiological context of chronic inflammatory diseases. This book then explores the local hormones that act as alarm signals following a local injury, which includes serotonin, histamine, kinins, heparin, prostaglandin, adenylates, lysolecithins, and catecholamines. Other chapters feature contributors who have active research on the clinical evaluation and treatment of severely debilitating chronic inflammatory diseases, including gout, arthritis, rheumatoid arthritis, osteoarthritis, psoriasis, and systemic lupus erythematosus. The final chapter explores the metabolism of anti-inflammatory drugs that are organized around chemical classes of compounds. This book is a valuable source of information for physicians, chemists, and experimental biologists.