Anthracycline Chemistry and Biology I: Biological Occurence and Biosynthesis, Synthesis and Chemistry (Topics in Current Chemistry, 282)

Front Matter....Pages I-XIV Front Matter....Pages 1-2 Naturally Occurring Anthracyclines....Pages 3-74 Biosynthetic Anthracycline Variants....Pages 75-99 Anthracycline Biosynthesis: Genes, Enzymes and Mechanisms....Pages 101-140 Front Matter....Pages 141-142 Synthesis of Enantiomerically Pure Anthracyclinones....Pages 143-186 Combinatorial Synthesis of Linearly Condensed Polycyclic Compounds, Including Anthracyclinones, Through Tandem Diels–Alder Additions....Pages 187-214 Fluorinated Anthracyclines....Pages 215-248 Synthesis of the Sugar Moieties....Pages 249-284 Nonnatural Glycosyl Anthraquinones as DNA Binding and Photocleaving Agents....Pages 285-298 Syntheses of Anthracyclines and Fredericamycin A via Strong Base-Induced Cycloaddition Reaction of Homophthalic Anhydrides....Pages 299-319 Back Matter....Pages 321-324 I. Biological occurence and biosynthesis, synthesis and chemistry II. Mode of action, clinical aspects and new drugs.