Anthracycline antibiotics : new analogues, methods of delivery, and mechanisms of action : developed from a symposium sponsored by the Division of Carbohydrate Chemistry at the 205th National Meeting of the American Chemical Society, Denver, Colorado, Mar

Content: Unresolved structure-activity relationships in anthracycline analogue development / Edward M. Acton -- Non-cross-resistant anthracyclines with reduced basicity and increased stability of the glycosidic bond / Waldemar Priebe, Piotr Skibicki, Oscar Varela, Nouri Neamati, Marcos Sznaidman, Krzysztof Dziewiszek, Grzegorz Grynkiewicz, Derek Horton, Yiyu Zou, Yi-He Ling, and Roman Perez-Soler -- Fluorinated anthracyclinones and their glycosylated products / Antonio Guidi, Franca Canfarini, Alessandro Giolitti, Franco Pasqui, Vittorio Pestellini, and Federico Arcamone -- Semisynthetic rhodomycins and anthracycline prodrugs / Cenek Kolar, Klaus Bosslet, Jörg Czech, Manfred Gerken, Peter Hermentin, Dieter Hoffmann, and Hans-Harold Sedlacek -- Synthetic options for reversal of anthracycline resistance and cardiotoxicity / Claude Monneret, Jean-Claude Florent, Jean-Pierre Gesson, Jean-Claude Jacquesy, François Tillequin, and Michel Koch -- Synthesis and biological activities of fluorinated daunorubicin and doxorubicin analogues / Tsutomu Tsuchiya and Yasushi Takagi -- Redox chemistry of anthracyclines and use of oxomorpholinyl radicals / Tad H. Koch and Giorgio Gaudiano -- Synthesis of anthraquinone analogues of linked anthracycline / Ping Ge and Richard A. Russell -- Synthesis and study of structure-activity relationships of new classes of anthracyclines / Antonino Suarato, Francesco Angelucci, Alberto Bargiotti, Michele Caruso, Daniela Faiardi, Laura Capolongo, Cristina Geroni, Marina Ripamonti, and Maria Grandi -- Molecular recognition of DNA by daunorubicin / Jonathan B. Chaires -- Adducts of DNA and anthracycline antibiotics : structures, interactions, and activities / Jasmine Y.-T. Wang, Mark Chao, and Andrew H.-J. Wang -- DNA topoisomerases and their inhibition by anthracyclines / Yves Pommier -- Anthracycline antihelicase action : new mechanism with implications for guanosine-cytidine intercalation specificity / Nicholas R. Bachur, Robin Johnson, Fang Yu, Robert Hickey, and Linda Malkas -- Membrane biophysical parameters influencing anthracycline action / Ratna Mehta and Thomas G. Burke -- Signal transduction systems in doxorubicin hydrochloride mechanism of action / Paul Vichi, James Song, Jean Hess, and Thomas R. Tritton -- Analysis of multidrug transporter in living cells : application to uptake and release of anthracycline derivatives by drug-resistant K562 cells / Arlette Garnier-Suillerot, Frédéric Frézard, Marie-Nicole Borrel, Elene Pereira, Jolanta Tarasiuk, and Marina Fiallo -- Role of reactive-oxygen metabolism in cardiac toxicity of anthracycline antibiotics / James H. Doroshow -- Amelioration of anthracycline-induced cardiotoxicity by organic chemicals / Donald T. Witiak and Eugene H. Herman -- Use of drug carriers to ameliorate the therapeutic index of anthracycline antibiotics / Roman Perez-Soler, Steven Sugarman, Yiyu Zou, and Waldemar Priebe. Unresolved Structure-activity Relationships In Anthracycline Analogue Development / Edward M. Acton -- Non-cross-resistant Anthracyclines With Reduced Basicity And Increased Stability Of The Glycosidic Bond / Waldemar Priebe, Piotr Skibicki, Oscar Varela, Nouri Neamati, Marcos Sznaidman, Krzysztof Dziewiszek, Grzegorz Grynkiewicz, Derek Horton, Yiyu Zou, Yi-he Ling, And Roman Perez-soler -- Fluorinated Anthracyclinones And Their Glycosylated Products / Antonio Guidi, Franca Canfarini, Alessandro Giolitti, Franco Pasqui, Vittorio Pestellini, And Federico Arcamone -- Semisynthetic Rhodomycins And Anthracycline Prodrugs / Cenek Kolar, Klaus Bosslet, Jörg Czech, Manfred Gerken, Peter Hermentin, Dieter Hoffmann, And Hans-harold Sedlacek -- Synthetic Options For Reversal Of Anthracycline Resistance And Cardiotoxicity / Claude Monneret, Jean-claude Florent, Jean-pierre Gesson, Jean-claude Jacquesy, François Tillequin, And Michel Koch --^ Synthesis And Biological Activities Of Fluorinated Daunorubicin And Doxorubicin Analogues / Tsutomu Tsuchiya And Yasushi Takagi -- Redox Chemistry Of Anthracyclines And Use Of Oxomorpholinyl Radicals / Tad H. Koch And Giorgio Gaudiano -- Synthesis Of Anthraquinone Analogues Of Linked Anthracycline / Ping Ge And Richard A. Russell -- Synthesis And Study Of Structure-activity Relationships Of New Classes Of Anthracyclines / Antonino Suarato, Francesco Angelucci, Alberto Bargiotti, Michele Caruso, Daniela Faiardi, Laura Capolongo, Cristina Geroni, Marina Ripamonti, And Maria Grandi -- Molecular Recognition Of Dna By Daunorubicin / Jonathan B. Chaires -- Adducts Of Dna And Anthracycline Antibiotics : Structures, Interactions, And Activities / Jasmine Y.-t. Wang, Mark Chao, And Andrew H.-j. Wang -- Dna Topoisomerases And Their Inhibition By Anthracyclines / Yves Pommier --^ Anthracycline Antihelicase Action : New Mechanism With Implications For Guanosine-cytidine Intercalation Specificity / Nicholas R. Bachur, Robin Johnson, Fang Yu, Robert Hickey, And Linda Malkas -- Membrane Biophysical Parameters Influencing Anthracycline Action / Ratna Mehta And Thomas G. Burke -- Signal Transduction Systems In Doxorubicin Hydrochloride Mechanism Of Action / Paul Vichi, James Song, Jean Hess, And Thomas R. Tritton -- Analysis Of Multidrug Transporter In Living Cells : Application To Uptake And Release Of Anthracycline Derivatives By Drug-resistant K562 Cells / Arlette Garnier-suillerot, Frédéric Frézard, Marie-nicole Borrel, Elene Pereira, Jolanta Tarasiuk, And Marina Fiallo -- Role Of Reactive-oxygen Metabolism In Cardiac Toxicity Of Anthracycline Antibiotics / James H. Doroshow -- Amelioration Of Anthracycline-induced Cardiotoxicity By Organic Chemicals / Donald T. Witiak And Eugene H. Herman --^ Use Of Drug Carriers To Ameliorate The Therapeutic Index Of Anthracycline Antibiotics / Roman Perez-soler, Steven Sugarman, Yiyu Zou, And Waldemar Priebe. Waldemar Priebe, Editor. Developed From A Symposium Sponsored By The Division Of Carbohydrate Chemistry At The 205th National Meeting Of The American Chemical Society, Denver, Colorado, March 28-april 2, 1993. Includes Bibliographical References And Indexes. Covers the synthesis of promising new analogues, and studies structure-activity relationships of anthracycline antibiotics. The book investigates new approaches to improving properties for anthracyclines by using different drug-delivery and tumour-targeting systems.