Annual Reports in Medicinal Chemistry, Volume 37 (Annual Reports in Medicinal Chemistry)

"Annual Reports in Medicinal Chemistry" provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Content: Contributors Page xi Preface Page xiii Annette M Doherty Chapter 1. Promise and progress of central G-protein coupled receptor modulators for obesity treatments Original Research Article Pages 1-10 Brian L Largent, Albert J Robichaud, Keith J Miller Chapter 2. Attention deficit hyperactivity disorder: Pathophysiology and design of new treatments Original Research Article Pages 11-20 Shelly A Glase, David W Robertson, Lawrence D Wise Chapter 3: 5-HT 2c receptor modulators: Progress in development of new CNS medicines Original Research Article Pages 21-30 Lawrence W Fitzgerald, Michael D Ennis Chapter 4. Emerging themes in Alzheimer's disease research: Paradigm shift in drug discovery Original Research Article Pages 31-40 Todd E Morgan, Grant A Krafft Chapter 5: Recent advances in pulmonary hypertension therapy Original Research Article Pages 41-52 Russell A Bialecki Chapter 6. Phosphodiesterase 5 inhibitors Original Research Article Pages 53-64 Andrew W Stamford Chapter 7. Antagonists of VILA-4 Original Research Article Pages 65-74 George W Holland, Ronald J Biediger, Peter Vanderslice Chapter 8. Purine and pyrimidine nucleotide (P2) receptors Original Research Article Pages 75-84 Kenneth A Jacobson Chapter 9. Anticoagulants: Inhibitors of the factor vila/tissue factor pathway Original Research Article Pages 85-94 Leslie A Robinson, Eddine M.K Saiah Chapter 10. The prospects for microbial genomics providing novel, exploitable, antibacterial targets Original Research Article Pages 95-104 Thomas J Dougherty, John F Barrett Chapter 11. The chemistry and biology of the tetracyclines Original Research Article Pages 105-114 Mark L Nelson Chapter 12. Intracellular signaling targets for cancer chemosensitization Original Research Article Pages 115-124 Thomas G Gesner, Stephen D Harrison Chapter 13. Emerging microtubule stabilizing agents for cancer chemotherapy Original Research Article Pages 125-132 David C Myles Chapter 14. Antiviral agents Original Research Article Pages 133-147 Nicholas A Meanwell, John F Kadow, Paul M Scola Chapter 15. Aerosol delivery of antibiotics Original Research Article Pages 149-158 Peter B Challoner Chapter 16. Therapeutic applications of non-peptidic δ-opioid agonists graham Original Research Article Pages 159-166 Graham N Maw, Donald S Middleton Chapter 17. Selective glucocorticoid receptor modulators Original Research Article Pages 167-176 Michael J Coghlan, Steven W Elmore, Philip R Kymt, Michael E Kort Chapter 18. Inhibitors of p38α MAP kinase Original Research Article Pages 177-186 Sarvajit Chakravarty, Sundeep Dugar Scios Inc Chapter 19. Expanding and exploring cellular pathways for novel drug targets Original Research Article Pages 187-196 Malcolm P Weir, John P Overington, Marlon Schwarz Chapter 20. Searching for Alzheimer's disease therapies in your medicine cabinet: The epidemiological and mechanistic case for NSAIDs and statins Original Research Article Pages 197-208 Robert B Nelson Chapter 21. Matrix metalloproteinases and the potential therapeutic role for matrix metalloproteinase inhibitors in chronic obstructive pulmonary disease(COPD) Original Research Article Pages 209-216 Kevin M Bottomley, Maria G Belvisi Chapter 22. Fc receptor structure and the design of anti-inflammatories: New therapeutics for autoimmune disease Original Research Article Pages 217-224 Geoffrey A Pietersz, Maree S Powell, Paul A Ramsland, P.Mark Hogarth Chapter 23. Tumor classification for tailored cancer therapy Original Research Article Pages 225-236 Fiona McLaughlin, Nick Lathangue Chapter 24. Advances in technologies for the discovery and characterization of ion channel modulators: Focus on potassium channels Original Research Article Pages 237-246 Valentin K Gribkoff, John E Starrett Jr. Chapter 25. Microwave-assisted chemistry as a tool for drug discovery Original Research Article Pages 247-256 Carolyn D Dzierba, Andrew P Combs Chapter 26. To market, to market - 2001 Original Research Article Pages 257-277 Patrick Bernardelli, Bernard Gaudillière, Fabrice Vergne Chapter 27. Biosimulation: Dynamic modeling of biological systems Original Research Article Pages 279-288 Kevin Hall, Rebecca Baillie, Seth Michelson Compound name, code number and subject index, vol. 37 Pages 289-295 Cumulative chapter titles keyword index, volumes 1–37 Pages 297-313 Cumulative NCE introduction index, 1983–2001 Pages 315-330 Cumulative NCE introduction index, 1983–2001, (by indication) Pages 331-350