Annual Reports in Medicinal Chemistry, Volume 35 (Annual Reports in Medicinal Chemistry)

**Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences which are expected to provide the basis for entirely new future therapies.** Content: Contributors Page ix Preface Page xi Annette M. Doherty Chapter 1. Metabotropic glutamate receptor modulators: Recent advances and therapeutic potential Original Research Article Pages 1-10 James A. Monn, Darryle D. Schoepp Chapter 2. Recent advances in selective serotonin receptor modulation Original Research Article Pages 11-20 Albert J. Robichaud, Brian L. Largent Chapter 3. Recent advances in development of novel analgesics Original Research Article Pages 21-30 Elizabeth A. Kowaluk, Kevin J. Lynch, Michael F. Jarvis Chapter 4. Secretase inhibitors as therapeutics for Alzheimer's disease Original Research Article Pages 31-40 Richard E. Olson, Lorin A. Thompson Chapter 5. Targeting nicotinic acetylcholine receptors: Advances in molecular design and therapies Original Research Article Pages 41-51 Jeffrey D. Schmitt, Merouane Bencherif Chapter 6. Recent developments in antitussive therapy Original Research Article Pages 53-62 John A. Hey, Neng-Yang Shih Chapter 7. Advances in the understanding and treatment of congestive heart failure (HF) Original Research Article Pages 63-72 John E. Macor, Mark C. Kowala Chapter 8. Recent advances in endothelin antagonism Original Research Article Pages 73-82 Gang Liu Chapter 9. Factor Xa inhibitors: Recent advances in anticoagulant agents Original Research Article Pages 83-102 Bing-Yan Zhu, Robert M. Scarborough Chapter 10. Antiplatelet therapies Original Research Article Pages 103-122 Joanne M. Smallheer, Richard E. Olson, Ruth R. Wexler Chapter 11. Anti-angiogenesis as a therapeutic strategy for cancer Original Research Article Pages 123-133 Wendy J. Fantl, Steven Rosenberg Chapter 12. Progress in the oxazolidinone antibacterials Original Research Article Pages 135-144 Robert C. Gadwood, Dean A. Shinabarger Chapter 13. Progress in macrolide and ketolide antibacterials Original Research Article Pages 145-155 Daniel T.W. Chu Chapter 14. Progress with antifungal agents and approaches to combat fungal resistance Original Research Article Pages 157-166 William J. Watkins, Thomas E. Renau Chapter 15. Matrix metalloproteinase inhibitors for treatment of cancer Original Research Article Pages 167-176 Jerry W. Skiles, Lauren G. Monovich, Arco Y. Jeng Chapter 16. Recent developments in antiretroviral therapies Original Research Article Pages 177-189 Tomas Cihlar, Norbert Bischofberger Chapter 17. Chemokines: Targets for novel therapeutics Original Research Article Pages 191-200 Bharat K. Trivedi, Joseph E. Low, Kenneth Carson, Gregory J. LaRosa Chapter 18. Inosine monophosphate dehydrogenase: Consideration of structure, kinetics, and therapeutic potential Original Research Article Pages 201-210 Jeffrey O. Saunders, Scott A. Raybuck Chapter 19. Recent advances in therapeutic approaches to type 2 diabetes Original Research Article Pages 211-220 John M. Nuss, Allan S. Wagman Chapter 20. Toward the development of α 1a adrenergic receptor antagonists Original Research Article Pages 221-230 Mark G. Bock, Michael A. Patane Chapter 21. Protein tyrosine phosphatase inhibition Original Research Article Pages 231-250 William C. Ripka Chapter 22. Cholesteryl ester transfer protein as a potential therapeutic target to improve the HDL to LDL cholesterol ratio Original Research Article Pages 251-260 James A. Sikorski, Kevin C. Glenn Chapter 23. Pharmacogenomics Pages 261-269 Kit Fun Lau, Hakan Sakul Chapter 24. Oligomerisation of G protein-coupled receptors Pages 271-279 Graeme Milligan, Stephen Rees Chapter 25. Immunomodulatory phosphorylcholine-containing proteins secreted by filarial nematodes Pages 281-288 William Harnett Chapter 26. Privileged structures — An update Original Research Article Pages 289-298 Arthur A. Patchett, Ravi P. Nargund Chapter 27. Ex vivo approaches to predicting oral pharmacokinetics in humans Original Research Article Pages 299-307 Barbra H. Stewart, Yi Wang Chapter 28. Inhibition of cysteine proteases Original Research Article Pages 309-320 Robert W. Marquis Chapter 29. Principles for multivalent ligand design Original Research Article Pages 321-330 Laura L. Kiessling, Laura E. Strong, Jason E. Gestwicki Section VII. Trends and perspectives Original Research Article Pages 331-356 Bernard Gaudilliere, Patrick Berna Chapter 31. Genetically modified crops as a source for pharmaceuticals Original Research Article Pages 357-364 Véronique Gruber, Manfred Theisen Compound name, code number and subject index, vol. 35 Pages 365-373 Cumulative chapter titles keyword index, volumes 1–35 Pages 375-390 Cumulative NCE introduction index, 1983–1999 Pages 391-405 Cumulative NCE introduction index, 1983–1999, (by indication) Pages 407-425 American chemical society division of medicinal chemistry Page 426 Introduction. Glutamate is considered the major excitatory neurotransmitter in the mammalian central nervous system, contributing input to the majority of excitatory synapses.