Animals in scientific research, an effective substitute for man? : proceedings of a symposium held in April 1982 under the auspices of the Humane Research Trust

Front Matter....Pages i-vii Front Matter....Pages 1-1 Introduction....Pages 3-5 A more scientific approach to the safety evaluation of chemicals....Pages 7-28 The use of short term tests to detect the carcinogenic and mutagenic potential of environmental chemicals....Pages 29-45 The design and use of in vitro toxicity tests....Pages 47-68 Drug metabolism and the safety evaluation of drugs and chemicals....Pages 69-79 A review of the value of isolated hepatocyte systems in xenobiotic metabolism and toxicity studies....Pages 81-90 Isolated human cellular models in clinical pharmacological studies....Pages 91-96 In vitro systems in the study of osteoarthritis....Pages 97-107 Uses and limitations of tissue culture in drug testing....Pages 109-118 Testing for delayed effects on development and differentiation: Some open questions....Pages 119-141 Front Matter....Pages 143-143 Introduction....Pages 145-146 Monitoring human and animal intrauterine development with non invasive methods and perfecting in vitro placental perfusion techniques for toxicologic and teratologic experiments....Pages 147-160 The role of mathematical models in biomedical research....Pages 161-177 Biocrystallography....Pages 179-201 Comparative medicine....Pages 203-209 Legislating against cruelty....Pages 211-220