Animal Models of Acute Neurological Injury (Springer Series in Translational Stroke Research)

Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. __Animal Models of Acute Neurological Injuries, Second Edition,__ provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation. As with the first edition, top experts have developed and contributed these animal models. The book’s focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. __Animal Models of Acute Neurological Injuries, Second Edition,__ is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field. Front Matter ....Pages i-x Front Matter ....Pages 1-1 Animal Protocol (Laurel D. Schantz)....Pages 3-12 Anesthesia and Analgesia for Research Animals (Lisa J. Brossia-Root, Tara M. Cotroneo, Gerry Hish)....Pages 13-34 Rodent Surgical Procedures and Tissue Collection (Cesar Reis, Onat Akyol, Jay Malaguit, Lei Huang, Budbazar Enkhjargal, Richard Applegate II et al.)....Pages 35-54 Brain Monitoring (Cesar Reis, Onat Akyol, Wing Man Ho, Richard Applegate II, Gary Stier, Robert Martin et al.)....Pages 55-69 Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies: An Update (Christine D. Yarberry, Aaron H. Puckett, Stephen M. Onifer)....Pages 71-90 Front Matter ....Pages 91-91 Four-Vessel Occlusion Model in Rats (Ping Deng, Zao C. Xu)....Pages 93-105 Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia (Ami P. Raval, Chunli Liu, Bingren R. Hu)....Pages 107-117 Rodent Model of Pediatric Asphyxial Cardiac Arrest (Mioara D. Manole, Henry L. Alexander, Robert W. Hickey, Robert S. B. Clark)....Pages 119-130 Transient Middle Cerebral Artery Occlusion Model in Rodents (Ying Mao, Wei Zhu, Guo-Yuan Yang)....Pages 131-143 Targeted Occlusion to Surface and Deep Vessels in Neocortex Via Linear and Nonlinear Optical Absorption (David Kleinfeld, Beth Friedman, Patrick D. Lyden, Andy Y. Shih)....Pages 145-162 Intraluminal Middle Cerebral Artery Occlusion Model in Mice (Masaya Oda, Taku Sugawara, Kohei Kokubun, Kazuo Mizoi, Hiroyuki Kinouchi)....Pages 163-172 Inducing Hemorrhagic Transformation Following Middle Cerebral Artery Occlusion via Acute Hyperglycemia in Rats (Devin W. McBride, Derek Nowrangi, Wing Mann Ho, Jiping Tang, John H. Zhang)....Pages 173-187 Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits (Zhongjie Shi, Kehuan Luo, Sidhartha Tan)....Pages 189-205 A Model of Neonatal Focal Cerebral Ischemia-Reperfusion (Zinaida S. Vexler, Donna M. Ferriero)....Pages 207-215 Front Matter ....Pages 217-217 Monofilament Perforation Subarachnoid Hemorrhage Rat Model (Wing Mann Ho, Cesar Reis, Onat Akyol, Julian Cahill, Devin McBride, John H. Zhang)....Pages 219-230 Filament Perforation Subarachnoid Hemorrhage Mouse Model (Hideyuki Kamii, Teiji Tominaga)....Pages 231-240 The Non-human Primate Model of Cerebral Vasospasm (R. Loch Macdonald)....Pages 241-256 Blood Injection Intracerebral Hemorrhage Rat Model (Thomas O’Lynnger, Shanshan Mao, Ya Hua, Guohua Xi)....Pages 257-262 Collagenase Model of Intracerebral Hemorrhage in Rats (Anatol Manaenko, Derek Nowrangi, Reis Cesar, Jiping Tang, John H. Zhang)....Pages 263-279 A Rat Model of Cerebellar Hemorrhage Using Bacterial Collagenase Injection (Devin W. McBride, Tim Lekic, Jiping Tang, John H. Zhang)....Pages 281-292 Blood Injection Intracerebral Hemorrhage Mouse Model (Ludmila Belayev)....Pages 293-302 Blood Injection Intracerebral Hemorrhage Pig Model (Yuxiang Gu, Shenglong Cao, Guohua Xi, Ya Hua)....Pages 303-309 Collagenase Induced Pontine Hemorrhage in Rats (Loretta O. Iniaghe, Devin W. McBride, Tim Lekic, Jiping Tang, John H. Zhang)....Pages 311-321 Germinal Matrix Hemorrhage Neonatal Rat Model Using Bacterial Collagenase Injection (Jerry J. Flores, Damon Klebe, Jiping Tang, John H. Zhang)....Pages 323-329 Front Matter ....Pages 331-331 Fluid Percussion Injury Model (Rachel K. Rowe, Daniel R. Griffiths, Jonathan Lifshitz)....Pages 333-347 The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol (Nicole Osier, Anthony E. Kline, C. Edward Dixon)....Pages 349-365 Mild Blast-Induced Traumatic Brain Injury Model (Riyi Shi, Nicholas Race)....Pages 367-378 A Rat Model of Surgical Brain Injury (Prativa Sherchan, Devin W. McBride, Lei Huang, Cesar Reis, Onat Akyol, Yuechun Wang et al.)....Pages 379-401 The MASCIS Spinal Cord Contusion Model (Wise Young)....Pages 403-414 The Ohio State University ESCID Spinal Cord Contusion Model (Lyn B. Jakeman, Dana M. McTigue, Patricia Walters, Bradford T. Stokes)....Pages 415-429 Cervical Hemicontusion Spinal Cord Injury Model (Philippa M. Warren, Basem I. Awad, Davina V. Gutierrez, Kevin C. Hoy, Michael P. Steinmetz, Warren J. Alilain et al.)....Pages 431-451 Applications of the Infinity Horizon Spinal Cord Contusion Injury Model (Samir P. Patel, Alexander G. Rabchevsky)....Pages 453-460 Clip Impact-Compression Model (Charles H. Tator, Peter Poon, Andrea J. Mothe)....Pages 461-474 Method of Spinal Cord Contusion Injury Created by Tissue Displacement (Yi Ping Zhang, Lisa B. E. Shields, Xiao-Ming Xu, Christopher B. Shields)....Pages 475-485 Experimental Laceration Spinal Cord Injury Model in Rodents (Yi Ping Zhang, Lisa B. E. Shields, Christopher B. Shields)....Pages 487-498 Rodent Spinal Cord Demyelination Models (Kariena R. Andres, Johnny R. Morehouse, Rachel Cary, Christine D. Yarberry, Nicholas J. Kuypers, Scott R. Whittemore)....Pages 499-512 Spinal Cord Lateral Hemisection and Implantation of Guidance Channels (Xiaofei Wang, Xiao-Ming Xu)....Pages 513-520 Spinal Root Avulsion and Repair (Tak-Ho Chu, Wutian Wu)....Pages 521-531 Back Matter ....Pages 533-544