Animal Clinical Chemistry : A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition

**10 Years? of Updates Since First Edition** Newcomers to the animal clinical chemistry and toxicology fields quickly find that the same rules of human medicine do not always apply. Following in the footsteps of its standard-setting first edition, **Animal Clinical Chemistry: __A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition__ collates information widely dispersed in journals and book chapters, focusing on the most-relevant literature to experimental toxicology and its distinction from human medicine.** **Expands Discussion of Troponins, Lipids, and Electrolytes** In addition to tests recommended by regulatory authorities, this globally relevant resource includes information about clinical chemistry tests as well as hepato-, nephro-, cardio-, and endocrine toxicity. It also covers pre-analytical and analytical variables, which play a far more important role with interpreting data from animal studies as compared to human studies when variables can be well-controlled with less physiological effect. Furthermore, this edition takes its discussion of biomarkers to the next level, exploring newer and related investigations, such as metabolomics/NMR and multiplex technology. Under the editorial guidance of G.O. Evans, a recognized field authority, the book presents background information on the selection and application of biochemical tests in preclinical safety assessment studies. It also assesses specific organ toxicity, such as in the liver, kidney, and thyroid, along with regulatory requirements and statistical approaches. Careful to avoid delving into overly complex detail, this text is a comprehensive, practical reference ideal for new entrants to the field. However, its broad scope and depth also make it suitable for more seasoned scientists and toxicologists.

10+ Years’ of Updates Since First Edition

Newcomers to the animal clinical chemistry and toxicology fields quickly find that the same rules of human medicine do not always apply. Following in the footsteps of its standard-setting first edition, Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition collates information widely dispersed in journals and book chapters, focusing on the most-relevant literature to experimental toxicology and its distinction from human medicine.

Expands Discussion of Troponins, Lipids, and Electrolytes

In addition to tests recommended by regulatory authorities, this globally relevant resource includes information about clinical chemistry tests as well as hepato-, nephro-, cardio-, and endocrine toxicity. It also covers pre-analytical and analytical variables, which play a far more important role with interpreting data from animal studies as compared to human studies when variables can be well-controlled with less physiological effect. Furthermore, this edition takes its discussion of biomarkers to the next level, exploring newer and related investigations, such as metabolomics/NMR and multiplex technology.

Under the editorial guidance of G.O. Evans, a recognized field authority, the book presents background information on the selection and application of biochemical tests in preclinical safety assessment studies. It also assesses specific organ toxicity, such as in the liver, kidney, and thyroid, along with regulatory requirements and statistical approaches. Careful to avoid delving into overly complex detail, this text is a comprehensive, practical reference ideal for new entrants to the field. However, its broad scope and depth also make it suitable for more seasoned scientists and toxicologists.

10+ Years of Updates Since First Edition Newcomers to the animal clinical chemistry and toxicology fields quickly find that the same rules of human medicine do not always apply. Following in the footsteps of its standard-setting first edition, Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition collates information widely dispersed in journals and book chapters, focusing on the most relevant literature to experimental toxicology and its distinction from human medicine. Expands Discussion of Troponins, Lipids, and Electrolytes In addition to tests recommended by regulatory authorities, this globally relevant resource includes information about clinical chemistry tests as well as hepato-, nephro-, cardio-, and endocrine toxicity. It also covers pre-analytical and analytical variables, which play a far more important role with interpreting data from animal studies as compared to human studies when variables can be well controlled with less physiological effect. Furthermore, this edition takes its discussion of biomarkers to the next level, exploring newer and related investigations, such as metabolomics/NMR and multiplex technology. Under the editorial guidance of G.O. Evans, a recognized field authority, the book presents background information on the selection and application of biochemical tests in preclinical safety assessment studies. It also assesses specific organ toxicity, such as in the liver, kidney, and thyroid, along with regulatory requirements and statistical approaches. Careful to avoid delving into overly complex detail, this text is a comprehensive, practical reference ideal for new entrants to the field. However, its broad scope and depth also make it suitable for more seasoned scientists and toxicologists. Appendix E: Some Common Biochemical Abbreviations......Page 0 Dog, Canis familiaris......Page 2 Guinea Pig, Cavia porcellus......Page 3 Micropigs......Page 4 Nonhuman Primate, Macaca fascicularis (Cynomolgus); Macaca artoides (Stump Tailed Monkey)......Page 5 Rat, Rattus norvegicus......Page 6 UNITS FOR VOLUMES, MASSES, AND MOLES......Page 8 MOLARITY AND MOLALITY......Page 9 OTHER NOTES......Page 10 Appendix C: "Expectable" Ranges for Plasma/Serum......Page 11 Ranges for Dogs (Beagles Aged 8–12 Months)......Page 12 Ranges for Ferrets......Page 13 Ranges for Guinea Pigs......Page 14 Ranges for Hamsters (Syrian)......Page 15 Ranges for Marmoset (Callithrix jacchus)......Page 16 Ranges for Mice (CD1)......Page 17 Ranges for Micropigs (Yucatan)......Page 18 Ranges for Monkeys (Cynomolgus)......Page 19 Ranges for Rabbits (New Zealand White)......Page 20 Ranges for Rats (Wistar Aged 6–12 Weeks)......Page 21 Appendix D: General Abbreviations......Page 22 Appendix E: Some Common Biochemical Abbreviations......Page 25 ANIMAL CLINICAL CHEMISTRY: A PRACTICAL GUIDE FOR TOXICOLOGISTS AND BIOMEDICAL RESEARCHERS, SECOND EDITION......Page 28 Contents......Page 30 The Editor......Page 39 Contributors......Page 40 Preface......Page 41