Angiogenesis Inhibition (Recent Results in Cancer Research Book 180)

Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials on therapeutic compounds are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in research and treatment in this exciting field. Front Matter....Pages i-xiv Introduction....Pages 1-1 Angiopoietins....Pages 3-13 HIF-1α and Cancer Therapy....Pages 15-34 Chemokines....Pages 35-50 Angiogenesis Inhibition in Cancer Therapy....Pages 51-81 Vascular Integrins: Therapeutic and Imaging Targets of Tumor Angiogenesis....Pages 83-101 PDGF and Vessel Maturation....Pages 103-114 Lymphangiogenesis in Cancer: Current Perspectives....Pages 115-135 Compounds in Clinical Phase III and Beyond....Pages 137-163 Metronomic Chemotherapy: Principles and Lessons Learned from Applications in the Treatment of Metastatic Prostate Cancer....Pages 165-183 Targeting Inflammatory Cells to Improve Anti-VEGF Therapies in Oncology....Pages 185-200 Antibody-Based Vascular Tumor Targeting....Pages 201-216 Caveolae and Cancer....Pages 217-231 Angiopoietins -- H1f-1 And Cancer Therapy -- Chemokines -- Angiogenesis Inhibition In Cancer Therapy -- Vascular Integrins: Therapeutic And Imaging Targets Of Tumor Angiogenesis -- Pdgf And Vessel Maturation -- Lymphangiogenesis In Cancer: Current Perspectives -- Compounds In Clinical Phase Iii And Beyond -- Metronomic Chemotherapy: Principles And Lessons Learned From Applications In The Treatment Of Metastatic Prostate Cancer -- Targeting Inflammatory Cells To Improve Anti-vegf Therapies In Oncology -- Antibody-based Vascular Tumor Targeting -- Caveolae And Cancer. Rüdiger Liersch, Wolfgang E. Berdel, Torsten Kessler (eds.). Includes Bibliographical References.