Angiogenesis: From The Molecular To Integrative Pharmacology (advances In Experimental Medicine And Biology)

Proceedings of the 5th Biannual International Meeting on Angiogenesis: From the Molecular to Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece. Angiogenesis, as a vastly complex biological process, has challenged researchers from all basic scientific disciplines, including pharmacology, biochemistry, physiology, embryology and anatomy. The significance of this phenomenon for the study of disease states has also interested clinicians from a number of specialist fields. This multidisciplinary work reflects the growth of awareness of concepts such as angiogenesis based therapy, the enormous therapeutic and commercial potential of which has attracted major research and investment in recent years. This volume, which aims to bridge the gap between basic and clinical methodology and understanding, presents the most up-to-date developments in this field. The book contains black-and-white illustrations. Front Matter....Pages i-x Introductory Comments....Pages 1-4 Front Matter....Pages 5-5 Examining New Models for the Study of Autocrine and Paracrine Mechanisms of Angiogenesis Through FGF2-Transfected Endothelial and Tumour Cells....Pages 7-34 Tie-1 Receptor Tyrosine Kinase Endodomain Interaction with SHP2: Potential Signalling Mechanisms and Roles in Angiogenesis....Pages 35-46 On the Mechanism(s) of Thrombin Induced Angiogenesis....Pages 47-55 Endothelial Receptor Tyrosine Kinases involved in Blood Vessel Development and Tumor Angiogenesis....Pages 57-66 Ontogeny of the Endothelial System in the Avian Model....Pages 67-78 Front Matter....Pages 79-79 The Role of Pericytes in Controlling Angiogenesis In Vivo ....Pages 81-99 Insights into the Vasodilation of Rat Retinal Vessels Evoked by Vascular Endothelial Growth Factor 121 (VEGF 121 )....Pages 101-108 Signal Transduction and Transcriptional Regulation of Angiogenesis....Pages 109-115 Differential Contribution of Bradykinin Receptors in Angiogenesis....Pages 117-128 Sensitivity of Different Vascular Beds in the Eye to Neovascularization and Blood-Retinal Barrier Breakdown in VEGF Transgenic Mice....Pages 129-138 Revascularization of Ischemic Tissues With Sikvav and Neuropeptide Y (Npy)....Pages 139-154 Cellular Effects and Signalling Pathways Activated by the Anti-Coagulant Factor, Protein S, in Vascular Cells....Pages 155-166 Front Matter....Pages 167-167 Targeting Integrins α v β 3 and α v β 5 for Bloking Tumor-Induced Angiogenesis....Pages 169-180 Suppression of Human Microvascular Endothelial Cell Invasion and Morphogenesis With Synthetic Matrixin Inhibitors....Pages 181-194 Front Matter....Pages 195-195 Tunicamycin Inhibits Capillary Endothelial Cell Proliferation by Inducing Apoptosis....Pages 197-208 The Characterization of Angiogenesis Inhibitor from Shark Cartilage....Pages 209-223 Quantitative Assays for the Chick Chorioallantoic Membrane....Pages 225-236 Front Matter....Pages 237-237 MYCN Oncogene and Angiogenesis: Down-Regulation of Endothelial Growth Inhibitors in Human Neuroblastoma Cells....Pages 239-248 From Hyperplasia to Neoplasia and Invasion: Angiogenesis in the Colorectal Adenoma - Carcinoma Model....Pages 249-266 Front Matter....Pages 237-237 Tumor Angiogenesis, Macrophages, and Cytokines....Pages 267-284 Microvessel Density, Thymidine Phosphorylase Expression and Resistance of Head and Neck Cancer to Chemo-Radiotherapy....Pages 285-289 Differential Expression of Angiogenic and of Vascular Survival Factors in Non-Small Cell Lung Cancer (NSCLC)....Pages 291-295 Thymidine Phosphorylase Activity in Normal, Hyperplastic and Neoplastic Endometrium - Correlation With Intratumoral Angiogenesis....Pages 297-303 Front Matter....Pages 305-305 Inhibition of VEGF Signal Transduction....Pages 307-310 Combretastatins Novel Vascular targeting Drugs for Improving Anticancer therapy....Pages 311-323 Front Matter....Pages 325-325 Therapeutic Angiogenesis for Ischemic Heart Disease....Pages 327-350 Back Matter....Pages 375-382