Analytical methods for therapeutic drug monitoring and toxicology [Recurs electrònic

This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters. Analytical Methods for Therapeutic Drug Monitoring and Toxicology......Page 1 Editors......Page 2 Copyright......Page 3 Dedication......Page 4 Contents......Page 5 Preface......Page 10 Monographs......Page 12 Abacavir......Page 13 Baclofen......Page 66 Caffeine......Page 83 Dabigatran Etexilate......Page 151 Ecabet Sodium......Page 193 Famotidine......Page 218 Gabapentin......Page 243 Haloperidol......Page 251 Ibafloxacin......Page 257 Kanamycin A......Page 276 Labetalol Hydrochloride......Page 283 Manidipine Hydrochloride......Page 309 Nadolol......Page 345 Octopamine......Page 369 Paclitaxel......Page 383 Quetiapine Fumarate......Page 419 Raltegravir Potassium......Page 422 Salicylic Acid......Page 434 Tacrine Hydrochloride......Page 456 Valacyclovir Hydrochloride......Page 481 Warfarin Sodium......Page 490 Zalcitabine......Page 491 Index......Page 499 US adopted name Drug category Chemical name Other names Molecular formula Molecular weight CAS number Appearance Solubilities pKa value(s) Individual(s) who developed or published the method Drug that was analyzed Description of analytical system components Description of major operating parameters Standard solution preparation Sample preparation (dilution, liquid-liquid or SPE extraction, derivatization, etc.) Dynamic concentration range of the calibration curve Correlation coefficient and linearity Coefficient of variation of the assay Intraday and interday coefficients of variation of samples Limit of detection and limit of quantification Interference. fmatter.pdf 1 Analytical Methods for Therapeutic Drug Monitoring and Toxicology 1 Editors 2 Copyright 3 Dedication 4 Contents 5 Preface 10 Monographs 12 Abacavir 13 Baclofen 66 Caffeine 83 Dabigatran Etexilate 151 Ecabet Sodium 193 Famotidine 218 Gabapentin 243 Haloperidol 251 Ibafloxacin 257 Kanamycin A 276 Labetalol Hydrochloride 283 Manidipine Hydrochloride 309 Nadolol 345 Octopamine 369 Paclitaxel 383 Quetiapine Fumarate 419 Raltegravir Potassium 422 Salicylic Acid 434 Tacrine Hydrochloride 456 Valacyclovir Hydrochloride 481 Warfarin Sodium 490 Zalcitabine 491 Index 499 Offering a compilation of summarized analytical methods designed, this book serves the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals.