Analysis of Amino Acid Sequences (Advances in Protein Chemistry, Volume 54) (Advances in Protein Chemistry)

Amino acid sequence analysis is useful for the study of problems ranging from modifications of single molecules to complex networks and interactions of species. Many available amino acid sequences are providing the basis for various studies at the proteome level. The dynamics of protein expression and the simulation of complex biological systems in which proteins interact with certain kinetics and in their respective compartments are just about to be tackled. Amino acid sequences will be crucial reference points for such studies. Key Features * Mass spectrometric analysis of proteins * Protein sequence databases * Amino acid substitution matrices * Amino acid-based phylogeny and alignment * Individual variation in protein-coding sequences of the human genome * Identifying nature's protein Lego(r) set Content: Preface Pages xi-xv Peer V Bork Mass spectrometric analysis of proteins Review Article Pages 1-30 Matthias Wilm Protein sequence databases Review Article Pages 31-71 Rolf Apweiler Amino acid substitution matrices Review Article Pages 73-97 Steven Henikoff, Jorja G Henikoff Amino acid-based phylogeny and alignment Review Article Pages 99-135 Desmond Ghiggins Searching databases to find protein domain organization Review Article Pages 137-157 Alex Bateman, Ewan Birney Identifying nature's protein lego set Review Article Pages 159-183 Sudeshna Das, Temple F Smith Evolution of domain families Review Article Pages 185-244 Chris P Ponting, Jörg Schultz, Richard R Copley, Miguel A Andrade, Peer Bork Protein fold recognition using sequence profiles and its application in structural genomics Review Article Pages 245-275 Eugene V Koonin, Yuri I Wolf, L Aravind Protein sorting signals and prediction of subcellular localization Review Article Pages 277-344 Kenta Nakai Gene and context: Integrative approaches to genome analysis Review Article Pages 345-379 Martijn A Huynen, Berend Snel Pathway databases and higher order function Review Article Pages 381-408 Minoru Kanehisa Individual variation in protein-coding sequences of human genome Review Article Pages 409-437 Shamil Sunyaev, Jens Hanke, David Brett, Atakan Aydin, Inga Zastrow, Warren Lathe, Peer Bork, Jens Reich Author index Pages 439-465 Subject index Pages 467-481 Amino acid sequence analysis is useful for the study of problems ranging from modifications of single molecules to complex networks and interactions of species. Many available amino acid sequences are providing the basis for various studies at the proteome level. The dynamics of protein expression and the simulation of complex biological systems in which proteins interact with certain kinetics and in their respective compartments are just about to be tackled. Amino acid sequences will be crucial reference points for such studies Protein-based molecular biological research has been considerably accelerated by the success with which mass spectrometric techniques are used to identify and sequence proteins from small amounts of samples.