مقدمه‌ای بر مسیرهای درد و «هدف‌های» درد

Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology. * Written by future leaders in the pain field * Covers a wide range of targets * Contains provocative ideas about the future direction of the pain field.

Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology.

• Written by future leaders in the pain field
• Covers a wide range of targets
• Contains provocative ideas about the future direction of the pain field.

Front Cover; Molecular and Cell Biology of Pain; Copyright; Contents; Contributors; Preface; Chapter 1: An Introduction to Pain Pathways and Pain T̀̀argets;́́ 1. An Introduction to Pain and Pain Pathways; 1.1. Neuropathic pain; 1.2. Inflammatory Pain; 2. Ion Channels, Receptors, and Other T̀̀argets ́́for Persistent Inflammatory or Neuropathic Pain; 2.1. Ion channels; 2.2. Sodium channels; 2.3. Calcium channels; 2.4. K+ channels; 2.5. Receptors; 2.6. Purinergic receptors; 2.7. Toll-like receptors; 2.8. PAR receptors; 2.9. Glutamate receptors; 2.10. AMPA receptors; 2.11. NMDA receptors