Amyloidosis

This book is a gift from the international community of amyloid friends, presented to Professor Dr. Enno Mandema on the occasion of his retirement from the University of Groningen, the Netherlands. It is the "precipitation" of up to date knowledge of amyloidosis, as presented at the International Course on Amyloidosis in Groningen, on the 10th and 11th of October 1986. Twenty years ago, Professor Mandema invited a group of scientists, who were studying the various aspects of amyloidosis from different points of view, to discuss their mutual interest in the subject. This "First International Symposium" was held for five days in September 1967. It was a wonderful experience for the participants, as most of them had until then only read each others work in the literature. The proceedings of that symposium, which contained the "lively" dis­ cussions, became a text-book for the following years. Research continued, and while the book was still in preparation, the revolutionary method of "water-soluble amyloid" was published. In the following years, different amyloid proteins were discovered and the mo­ lecular basis of the different amyloid syndromes was elucidated. The increase in knowledge parallelled the availability of modern, ingenious and also rapid methods in the biomedical sciences. Front Matter....Pages I-XVI Front Matter....Pages 1-1 General Introduction and a Brief History of Amyloidosis....Pages 3-19 Front Matter....Pages 21-21 Amyloid Proteins....Pages 23-34 Carbohydrate-Containing AL Proteins....Pages 35-37 Endocrine Amyloid Fibril Proteins....Pages 39-42 Amyloid P-Component: Structure and Properties....Pages 43-49 A Brief Review of the Ultrastructure of Amyloid....Pages 51-57 Front Matter....Pages 59-59 Clinical Evaluation of AA and AL Amyloid Disease....Pages 61-72 Cardiac Involvement in Amyloidosis....Pages 73-82 Hemodialysis-Associated Amyloid of β 2 -Microglobulin Nature....Pages 83-89 Amyloid P-Component: Clinical Implications....Pages 91-98 Front Matter....Pages 99-99 Amyloid Protein AA and its Precursor, The Acute Phase Protein(s) ApoSAA: A Perspective....Pages 101-106 Sites and Regulation of Biosynthesis of SAA....Pages 107-113 Serum Amyloid A Protein in Plasma: Characteristics of Acute Phase HDL....Pages 115-125 Correlation Between Sequence Variability and Structure Prediction in AA Proteins....Pages 127-133 Gene Structure of a Human Serum Amyloid A Protein and Comparison with Amyloid A....Pages 135-139 Structure and Expression of Murine Serum Amyloid A Protein Genes: Implications for Amyloidogenesis....Pages 141-148 Amyloidogenic Proteins in Human Central Nervous System Diseases....Pages 149-157 Structure of the Alzheimer Paired Helical Filament....Pages 159-167 The Significance of Non-Protein AA Material in Water-Soluble Bovine AA-Amyloid Fibrils....Pages 169-175 Fibril Derived Amyloid Enhancing Factor (FAEF) in Hamster: Evidence for a Close Relationship between AEF and AA-Amyloid Fibrils....Pages 177-182 Front Matter....Pages 183-183 The Hereditary Amyloidoses....Pages 185-193 Familial Amyloidotic Polyneuropathies....Pages 195-218 Biochemical and Genetic Characterization of a Variant Transthyretin Causing Familial Amyloidotic Polyneuropathy....Pages 219-223 Front Matter....Pages 225-225 The Nature and Pathogenesis of the Amyloid Deposits in Alzheimer’s Disease....Pages 227-242 Biochemistry of Cerebral Amyloid in Alzheimer’s Disease, The Unconventional Slow Virus Diseases and Icelandic Cerebrovascular Amyloidosis....Pages 243-253 Amyloid of the Islets of Langerhans and its Connection with Diabetes Mellitus....Pages 255-259 Senile Amyloid Affecting the Heart....Pages 261-265 Amyloid Arthropathy....Pages 267-270 Peripheral Angiopathy....Pages 271-282 Animal Models....Pages 283-291 Front Matter....Pages 293-293 Pathology of Experimental Amyloidosis....Pages 295-300 What Factors are Necessary for the Induction of AA Amyloidosis?....Pages 301-310 Amyloidogenic Proteins in Mice....Pages 311-318 Sites of SAA/AA Synthesis....Pages 319-327 The Role of the Macrophage Phagocytic System (MPS) in the Development of Secondary Amyloidosis....Pages 329-336 SAA Kinetics in Animals....Pages 337-340 Amyloid and Female Protein: Sex-Related Occurrence in the Syrian Hamster....Pages 341-346 Endocrine Amyloid in Animals....Pages 347-349 Dietary Treatment during the Induction and Resorption Phases of Experimental Amyloidosis....Pages 351-354 Front Matter....Pages 355-355 Future Directions in Amyloid Research....Pages 357-363 Back Matter....Pages 365-378