Amyloid Protein Precursor In Development, Aging And Alzheimer's Disease (research And Perspectives In Alzheimer's Disease)

This book summarizes the last ten years' research on Alzheimer's disease. Genetic mutations in the gene which codes for amyloid precursor protein (APP) have now been shown to cause Alzheimer's disease in some families. Other genetic loci are now being discovered which relate to Alzheimer's disease in some families. Understanding the normal structure and function of the APP gene product will eventually provide avenues for developing specific therapeutic strategies targeted at the amyloid deposition in the Alzheimer's disease brain. Drugs which can inhibit or dissolve the amyloid, affect the synthesis and proteolysis of APP, or which regulate the activity of the APP gene all hold the promise of eventually yielding an effective treatment for Alzheimer's disease. Front Matter....Pages I-XX Strategic Thoughts on the Alzheimer’s Disease Amyloid Protein Precursor: The Way Forward....Pages 1-8 Drosophila Appl Gene and APPL Protein: A Model System to Study the Function of the APP Protein Family....Pages 9-20 Amyloid β A4 of Alzheimer’s Disease: Structural Requirements for Folding and Aggregation....Pages 21-35 Production of Amyloid β Protein from Normal and Mutated Amyloid β Protein Precursors....Pages 36-45 Mechanism of Cerebral Amyloidosis in Alzheimer’s Disease....Pages 46-59 Effects of Fragments of the 2 -Amyloid Protein on Hippocampal Neurons in Young and Aged Rats: An Electrophysiological Study....Pages 60-64 The Role of the Extracellular Matrix in Regulating the Function of the Amyloid Protein Precursor of Alzheimer’s Disease....Pages 65-75 Studies of the Amyloid Precursor Protein (APP) in Brain: Regulation of APP-Ligand Binding....Pages 76-89 The Biological Function of Amyloid β/A4 Protein Precursor....Pages 90-99 Processing of Alzheimer A β -Amyloid Precursor Protein: Cell Biology, Regulation, and Role in Alzheimer’s Disease....Pages 100-120 Studies of APP Biology: Analysis of APP Secretion and Characterization of an APP Homologue, APLP2....Pages 121-133 Transmembrane APP is Distributed into Two Pools and Associated with Polymerized Cytoskeleton....Pages 134-138 Isolation and Characterisation of Novel Metalloproteases from Embryonic Mouse Hippocampus....Pages 139-143 A Transgenic Mouse Model of Alzheimer’s Disease....Pages 144-155 Amyloid in Alzheimer’s Disease and Animal Models....Pages 156-168 The Roles of Zinc and Copper in the Function and Metabolism of the Amyloid Protein Precursor Superfamily....Pages 169-180 The Diverse Molecular Nature of Inherited Alzheimer’s Disease....Pages 181-189 Genetic Variability and Alzheimer’s Disease....Pages 190-198 Genetic Defects in Early Onset Alzheimer’s Disease and Related Disorders....Pages 199-208 APP Gene Mutations in Familial Alzheimer’s Disease in Sweden....Pages 209-215 Aging, Energy and Alzheimer’s Disease....Pages 216-227 Molecular Biology and Genetics of Human Prion Diseases and PrP Amyloid Plaque Formation....Pages 228-253 Back Matter....Pages 255-259 This volume contains a summary of ten years' research on Alzheimer's disease. Emphasis is placed on an understanding of the normal function and structure of the amyloid precursor protein (APP) gene product, which is being used to develop specific therapeutic strategies. C.l Masters ... [et Al.] (eds.). Proceedings Of The Ninth Colloque Médecine Et Recherche ... Held In Lyon On June 21, 1993--pref. Includes Bibliographical References And Index.