Aminoacyl-tRNA Synthetases in Biology and Medicine (Topics in Current Chemistry Book 344)

This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed. 1 Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases John J. Perona, Ita Gruic-Sovulj 2 Emergence and Evolution Tammy J. Bullwinkle, Michael Ibba 3 Architecture and Metamorphosis Min Guo, Xiang-Lei Yang 4 Protein-Protein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases Jong Hyun Kim, Jung Min Han, Sunghoon Kim 5 Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for Cell-Cell Communication Sung Hwa Son, Min Chul Park, and Sunghoon Kim 6. Non-catalytic Regulation of Gene Expression by Aminoacyl-tRNA Synthetases Peng Yao, Kiran Poruri, Susan A. Martinis, Paul L. Fox 7 Amino-Acyl tRNA Synthetases Generate Dinucleotide Polyphosphates as Second Messengers: Functional Implications Sagi Tshori, Ehud Razin, Hovav Nechushtan 8 Association of Aminoacyl-tRNA Synthetases with Cancer Doyeun Kim, Nam Hoon Kwon, Sunghoon Kim 9 Pathogenic Implications of Human Mitochondrial Aminoacyl-tRNA Synthetases Hagen Schwenzer, Joffrey Zoll, Catherine Florentz, Marie Sissler 10 Role of Aminoacyl-tRNA Synthetases in Infectious Diseases and Targets for Therapeutic Development Varun Dewan, John Reader, Karin-Musier Forsyth 11 Flexizymes, Their Evolutionary History and Diverse Utilities Toby Passioura, Hiroaki Suga Front Matter....Pages i-x Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases....Pages 1-41 Emergence and Evolution....Pages 43-87 Architecture and Metamorphosis....Pages 89-118 Protein–Protein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases....Pages 119-144 Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for Cell–Cell Communication....Pages 145-166 Non-catalytic Regulation of Gene Expression by Aminoacyl-tRNA Synthetases....Pages 167-187 Amino-Acyl tRNA Synthetases Generate Dinucleotide Polyphosphates as Second Messengers: Functional Implications....Pages 189-206 Association of Aminoacyl-tRNA Synthetases with Cancer....Pages 207-245 Pathogenic Implications of Human Mitochondrial Aminoacyl-tRNA Synthetases....Pages 247-292 Role of Aminoacyl-tRNA Synthetases in Infectious Diseases and Targets for Therapeutic Development....Pages 293-329 Flexizymes, Their Evolutionary History and Diverse Utilities....Pages 331-345 Back Matter....Pages 347-350