Amine oxidases and their impact on neurobiology : proceedings of the 4th International Amine Oxidases Workshop, Würzburg, Federal Republic of Germany, July 7-10, 1990

Front Matter....Pages I-XII Front Matter....Pages 1-1 The interaction of transport mechanisms and intracellular enzymes in metabolizing systems....Pages 3-18 In-vivo quantitative imaging of catecholaminergic nerve terminals in brain and peripheral organs using positron emission tomography (PET)....Pages 19-27 The mechanism of action of antidepressants revised....Pages 29-37 Front Matter....Pages 39-39 The expression of human MAO-A and B genes....Pages 41-47 Molecular neuroanatomy of MAO-A and MAO-B....Pages 49-53 Turnover of monoamine oxidase B (MAO-B) in pig brain by positron emission tomography using 11 C-L-deprenyl....Pages 55-59 Visualisation of brain monoamine oxidase B (MAO-B) in dementia of Alzheimer’s type by means of large cryosection autoradiography: a pilot study....Pages 61-65 Immuno-fluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of monoamine oxidase A and monoamine oxidase B: a pilot study....Pages 67-77 Effect of selective and reversible MAO inhibitors on dopamine outflow in rat striatum: a microdialysis study....Pages 79-84 In vivo studies on the effect of monoamine oxidase inhibitors on dopamine and serotonin metabolism in rat brain areas....Pages 85-88 Some pharmacological implications of MAO-mediated deamination of branched aliphatic amines: 2-Propyl-1-aminopentane and N-(2-propylpentyl)glycinamide as valproic acid precursors....Pages 89-92 [ 3 H] Harman labels selectively and with high affinity the active site of monoamine oxidase (EC 1.4.3.4) subtype A (MAO-A) in rat, marmoset, and pig....Pages 93-102 Inhibition of MAO by substituted tryptamine analogues....Pages 103-105 Ring-substituted analogues of tranylcypromine as monoamine oxidase inhibitors....Pages 107-112 Recent studies on the MAO inhibitor phenelzine and its possible metabolites....Pages 113-118 Stylbasole analogues of MPTP as monoamine oxidase (MAO) substrates....Pages 119-122 MAO activity, metabolism and anticonvulsant activity of milacemide in rats and mice....Pages 123-129 Kinetic evaluation of MAO-B-activity following oral administration of selegiline and desmethyl-selegiline in the rat....Pages 131-137 Effect of selegiline and desmethyl-selegiline on cortical electric activity in rats....Pages 139-144 An enzymatic method for detecting MAO-A and MAO-B inhibitors in plasma and its application in studies with reversible MAO-A selective inhibitors....Pages 145-148 Front Matter....Pages 39-39 Serotonin and 5-hydroxyindoleacetic acid in plasma. Potential use as peripheral measures of MAO-A activity....Pages 149-154 Role of monoamine oxidase A and B in the deamination of newly-formed dopamine in the rat kidney....Pages 155-159 Monoamine oxidase activity in blood platelets of migraine patients....Pages 161-164 Monoamine oxidase inhibition by moclobemide and 2-Aminoethyl carboxamide derivatives: mode of action and kinetic characteristics....Pages 165-170 Does moclobemide stimulate melatonin synthesis as the other selective MAO-A inhibitors do?....Pages 171-175 Efficacy and safety of moclobemide compared with imipramine in the treatment of major depressive disorder. Double-blind Multicenter Study, Austria....Pages 177-184 Psychometric alterations in treatment with the MAO-A-inhibitor moclobemide....Pages 185-188 Clinical, biochemical and psychometric findings with the new MAO-A-inhibitors moclobemide and brofaromine in patients with major depressive disorder....Pages 189-195 Brofaromine (CGP 11 305 A): estimation of plasma concentrations by a biologic technique as compared to liquid chromatography....Pages 197-201 A double-blind, placebo-controlled study of the tolerability and effects on platelet MAO-B activity of single oral doses of MDL 72.974A in normal volunteers....Pages 203-209 MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time-course....Pages 211-214 Front Matter....Pages 215-215 Monoamine oxidase and the bioactivation of MPTP and related neurotoxins: relevance to DATATOP....Pages 217-227 Monoamine oxidase and oxidative stress at dopaminergic synapses....Pages 229-238 The role of monoamine oxidase, iron-melanin interaction, and intracellular calcium in Parkinson’s disease....Pages 239-248 Oxidation of the indole nucleus of 5-hydroxytryptamine and formation of dimers in the presence of peroxidase and H 2 O 2 ....Pages 249-257 Reflection of changes in membrane constituents in various regions of Alzheimer brains to differential scanning thermograms....Pages 259-267 Effects of L-deprenyl and amantadine in an MPTP-model of parkinsonism....Pages 269-275 Front Matter....Pages 277-277 Some aspects of the pharmacology of semicarbazide-sensitive amine oxidases....Pages 279-290 Intestinal diamine oxidases and enteral-induced histaminosis: studies on three prognostic variables in an epidemiological model....Pages 291-314 Methylamine oxidase from Arthrobacter P1 as a prototype of eukaryotic plasma amine oxidase and diamine oxidase....Pages 315-318 Front Matter....Pages 277-277 Chronic ethanol feeding and diamine oxidase activity in rat brain and liver....Pages 319-322 Amine oxidase activities in chemically-induced mammary cancer in the rat....Pages 323-326 Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in bovine eye....Pages 327-330 Cultured preadipocytes produce a semicarbazide-sensitive amine oxidase (SSAO) activity....Pages 331-336 Semicarbazide-sensitive amine oxidase activity in rat aortic cultured smooth muscle cells....Pages 337-339 Amine oxidase activities in bovine lung....Pages 341-344 Mucosal mono- and polyamine oxidase activities in digestive tract are distributed complementary to diamine oxidase....Pages 345-349 Does FAD-dependent polyamine oxidase contribute to the metabolism of milacemide?....Pages 351-356 Behaviour and properties of catechol-O-methyltransferase from human placenta....Pages 359-368 Monoclonal antibodies recognizing both soluble and membrane bound catechol-O-methyltransferase....Pages 369-374 Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues....Pages 375-380 Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-DOPA in the rat....Pages 381-386 Effect of the new selective COMT inhibitor CGP 28014 A on the formation of 3-O-methyldopa (3OMD) in plasma of healthy subjects....Pages 387-391 Front Matter....Pages 393-393 Oxidative deamination of noradrenaline in human blood vessels....Pages 395-404 Modification of alpha-2 presynaptic receptor activity and catecholamine release following chronic MAO inhibition....Pages 405-412 Biochemical characterization and purification of the neuronal sodium-dependent noradrenaline transporter....Pages 413-419 The importance of plasma 3,4-dihydroxyphenylglycol (DOPEG) in analyses of the sympathetic nervous system in vivo....Pages 421-429 The involvement of desipramine-sensitive processes in the extraction of various catecholamines from plasma in the anaesthetized rabbit....Pages 431-435 Human Caki-1 cells are the first model for extraneuronal transport of noradrenaline (uptake 2 ) which is based on a clonal cell line....Pages 437-440 The synaptic noradrenaline concentration in humans as estimated from simultaneous measurements of plasma noradrenaline and dihydroxyphenylglycol (DOPEG)....Pages 441-445 Front Matter....Pages 393-393 Inhibition of MAO activity, 3 H-imipramine binding, 3 H-paroxetine binding and 3 H-5-HT uptake by human cerebrospinal fluid....Pages 447-456 α 2 -Adrenoceptor responsivity in depression: effect of chronic treatment with moclobemide, a selective MAO-A-inhibitor, versus maprotiline....Pages 457-461 Supersensitivity to catecholamines after inhibition of extraneuronal uptake (uptake 2 ) or O-methylation....Pages 463-467 Front Matter....Pages 469-469 Urinary dopamine sulfate: regulations and significance in neurological disorders....Pages 471-479 Effect of adrenal-caudate transplantation on CSF levels of salsolinol sulfate in patients with Parkinson’s disease....Pages 481-484 Back Matter....Pages 485-491 The Amine Oxidase Workshop was the brain child of Brian Callingham and Keith Tipton. The present book is the proceedings of the fourth in the series and in the past we have dedicated our meeting to individuals who have made significant fundamental contributions to the biochemistry, physiology and pharmacology of this interesting group of enzymes. The present meeting is not an exception because we have gathered here in Wtirzburg to honour an individual whose outstanding work on the autonomic pharmacology has span ned more than 30 years and whose contribution has made a vast impact in our understanding of the kinetic relationship between amine metabolism (that uptake and enzymatic inactivation) and adrenergic neurotransmission. We speak of course of Professor Ullrich Trendelenburg, or Ulli as he likes to be known. Like the amine oxidases, he has a unique place in Pharmacology. Professor Trendelenburg was born on the eve of the new year of 1922 in the city of Rostock in northern Germany, where his father was Professor of Pharmacology at the Faculty of Medicine of Rostock. His father accepted the offer to take over the corresponding chair in Freiburg im Breisgrau (in Southern Germany). As the youngest of four children, Ulli grew up mainly in the garden of the department, in the animal quarters and in the workshop. Of the various coworkers of his father, one he liked especially was Otto Krayer, the young pharmacologist