بیماری آلزایمر: درک بیومارکرها، داده‌های کلان و درمان

Nearly 44 million people have Alzheimer's or a related dementia worldwide, according to the Alzheimer's Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Recent Advancement in Alzheimer's Disease Research: Neural and Cognitive Studies aims to cover all recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer's and other forms of dementia. First, readers are introduced to the cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to symptoms and the quality of life in Alzheimer's disease. In addition, the author discusses recent studies on memory dysfunction in advanced-stage Alzheimer's disease, in comparison to early-stage Alzheimer's disease; including a chapter on the factors underlying transition from mild cognitive impairment to Alzheimer's disease. Following this section, the author presents recent studies on the role of different cortical and subcortical structures in the development of different symptoms in Alzheimer's disease as well as different neural biomarkers underlying the development and treatment of Alzheimer's disease. In the last section of the book, therapeutic aspects of Alzheimer's disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, in Alzheimer's disease are reviewed. Recent Advancement in Alzheimer's Disease Research: Neural and Cognitive Studies aid readers with keeping up with the advances in research and care making it making it a prime tool for all clinicians, psychologists, researcher, neurologists, and caregivers of patients. Reviews recent developments of cognitive and clinical studies Covers factors underlying transition from mild cognitive impairment to Alzheimer's disease Discusses different neural biomarkers underlying the development and treatment of Alzheimer's disease Provides a comparison on the effectiveness of various types of treatments Front Cover Alzheimer’s Disease Copyright Page Dedication Contents List of contributors Acknowledgments I. Mental health in dementia 1 Measures of depression in Alzheimer’s disease Introduction Measures of depression in AD Discussion and conclusion References 2 The nature of depression in dementia: a narrative review Introduction: the diagnosis, prevalence, and impact of depression in dementia Methods Depression as a risk factor for dementia Subtypes of depression in dementia Depression and insight Depression in subtypes of dementia: relation to insight Conclusions and future work References 3 Stress and anxiety in dementia Dementia background Mental health in dementia Anxiety and dementia Anxiety as a risk factor for dementia The prevalence of anxiety in different types of dementia Anxiety in early versus late stages of dementia Stress and dementia Psychological stress, MCI, and dementia Childhood stress, midlife stress, and dementia Posttraumatic stress disorder in dementia Conclusions References II. Advanced topics in dementia research 4 Alzheimer’s disease in the pupil: pupillometry as a biomarker of cognitive processing in Alzheimer’s disease Introduction Method The case study Procedures and materials Results Discussion References 5 Cognitive and neural correlates of vitamin D deficiency: focus on healthy aging and Alzheimer’s disease Introduction Animal studies on cognitive function and vitamin D levels Healthy aging, dementia, and Alzheimer’s disease Conclusion Future implications Ethics approval and consent to participate Consent for publication Availability of data and material Competing interests Funding Authors’ contributions References 6 The effect of Alzheimer’s disease on the thalamus Introduction The effects of Alzheimer’s disease on the thalamus Volume reduction Nerve cell loss Thalamus’s link to other parts of the brain Hippocampus Papez circuit Retrosplenial cortex Thalamocortical network Prefrontal-striatal loops and the medial prefrontal cortex Discussion Future work Conclusion References 7 Using big data methods to understand Alzheimer’s disease Introduction What is Alzheimer’s disease? What causes Alzheimer’s disease? Are there treatments for Alzheimer’s disease? How do researchers study Alzheimer’s disease? Problems with standard Alzheimer’s disease research Big data methods What are databases? The advantages of databases Common difficulties with databases Big data analysis Statistical modeling Computational modeling The clinical applications of predictive models Example: the Alzheimer’s Disease Neuroimaging Initiative Data types Mixed predictor models Conclusion References 8 Operational aspects of deep learning solutions for Alzheimer’s disease Introduction Traditional Alzheimer’s CAD method trends Introduction CAD methods in AD research Data preprocessing Feature extraction Classification External influences on the application of the model Conclusion Alzheimer’s in the deep learning context Introduction The transition Deep learning model tasks Segmentation Feature extraction Classification Common model architectures LeNet-5 UNET Visual Geometry Group ResNet InceptionV4 Advantages of using deep learning End-to-end learning Increased accuracy Transfer learning Robustness Scalability Limitations of using deep learning Conclusion References III. Treatment of dementia 9 Treatment of depression in Alzheimer’s disease Introduction Treatment Pharmacological treatment Behavioral treatment Conclusions References 10 Developing a Vulnerability to Negative Affect in Dementia Scale (VNADS) for music interventions Introduction Method Item development Pretesting the items Piloting the VNADS (proxy) with people with dementia Results Pretest of version 1 Pilot of the VNADS (proxy) Discussion Funding Conflict of interests Acknowledgments References 11 Using music to improve mental health in people with dementia Introduction Music therapy Anxiety and agitation Mood and depression Nontherapist-led music interventions Well-being, anxiety, mood Negative versus positive impact of music interventions Theories of how music therapies and interventions work Conclusions and future studies References 12 The efficacy of donepezil for the treatment of Alzheimer’s disease Introduction The effects of donepezil in Alzheimer’s disease The effects of donepezil on the neuropsychological symptoms of AD The adverse effects of donepezil The potential effects of donepezil in AD Combined treatments involving donepezil Combined cognitive stimulation therapy and donepezil treatment Combined donepezil and memantine treatment Conclusion References Index Back Cover Nearly 44 million people have Alzheimer’s or related dementia worldwide, according to the Alzheimer’s Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer’s and other forms of dementia.

First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer’s disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer’s disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer’s diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer’s disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer’s disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients.

• Reviews recent developments of cognitive and clinical studies
• Covers factors underlying the transition from mild cognitive impairment to Alzheimer’s disease
• Discusses different neural biomarkers underlying the development and treatment of Alzheimer’s disease
• Provides a comparison of the effectiveness of various types of treatments

Nearly 44 million people have Alzheimer's or related dementia worldwide, according to the Alzheimer's Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer's and other forms of dementia. First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer's disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer's disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer's diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer's disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer's disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients. Reviews recent developments of cognitive and clinical studies Covers factors underlying the transition from mild cognitive impairment to Alzheimer's disease Discusses different neural biomarkers underlying the development and treatment of Alzheimer's disease Provides a comparison of the effectiveness of various types of treatments "Reviews recent developments of cognitive and clinical studies Covers factors underlying transition from mild cognitive impairment to Alzheimer's disease Discusses different neural biomarkers underlying the development and treatment of Alzheimer's disease Provides a comparison on the effectiveness of various types of treatments"-- Provided by publisher