Alzheimer's Disease Decoded: The History, Present, And Future Of Alzheimer's Disease And Dementia The History, Present, and Future of Alzheimer's Disease and Dementia

"The book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a "global" perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world. Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research. Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease. Dr. Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective. This book with appeal to a wide audience, regardless of their scientific or educational background."--[Source inconnue]. Read more... Abstract: "The book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a "global" perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world. Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research. Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease. Dr. Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective. This book with appeal to a wide audience, regardless of their scientific or educational background."--[Source inconnue] Contents 8 About the Authors 10 Building a Community 16 Foreword 18 Preface 20 Quick Reference Guide 28 Part I: Introduction, History, and Overview 30 Chapter 1: Introduction to the Brain and Nervous System 32 Human Brain: Structure 34 The Nervous System 38 Human Brain: Building Blocks 39 Human Brain: Plasticity 45 Human Brain: Development 46 Human Brain: Organization 48 Human Brain: Memory and Integration 50 Studying the Brain 54 References 56 Chapter 2: Dysfunction 60 Normal Age-related Changes 61 Smell 65 Nervous System Damage and Neurogenesis 69 Neurogenesis in Alzheimer’s and Brain Tumors 70 References 74 Chapter 3: Senility and Normal Aging 78 Is Alzheimer’s Disease a Normal Part of Aging? 78 Where did the Term “Senility” Come From and Why is it Ubiquitously Associated with Aging? 80 Cognitive Reserve 81 References 85 Chapter 4: What is Dementia? 88 What Causes Dementia and Alzheimer’s Disease? 93 References 99 Chapter 5: Introduction to Alzheimer’s Disease 102 Clinical Symptoms 105 Differential Diagnosis 108 Pathological findings 114 Plaques 114 Tangles 118 Cerebral Amyloid Angiopathy 119 Glial Cell Changes 119 Neuronal and Synaptic Loss 120 Macroscopic Changes 121 Cause of Death 122 Natural History 123 References 126 Chapter 6: Epidemiology of Alzheimer’s Disease 128 Gender and Ethnicity 129 Brain Size and Function 130 Genetics 130 Hormones 130 Social and Behavioral Effects 132 Smoking 133 Ethnicity 134 Global Effects 135 National Effects 138 References 141 Chapter 7: The History of Alzheimer’s Disease 150 The Characterization of the Disease by Dr. Alzheimer in the Early 1900s 150 The Development of the Diagnostic Tools 154 The Development of Medications 156 Clinical Trials Overview 160 Solanezumab 164 References 166 Chapter 8: An Interesting Link 168 Human Brain: Evolution 168 Three Types of Alzheimer’s Disease 171 Trisomy 21 (Down Syndrome) 174 The Interesting Role of Sleep in Alzheimer’s Disease 175 References 178 Part II: Novel Therapies and Future Directions 182 Chapter 9: Surgical Treatments for Dementia 184 Introduction to Neurosurgery and the “Miraculous” Cures of Dementiain Select Disorders 185 Surgical Clinical Trials: The Ventriculo- Peritoneal (UP) Shunt Trial 187 Stem Cell Trials: Pre-clinical Data and Clinical Trials 188 Deep-Brain Stimulation 191 References 193 Chapter 10: Is There a Link to Traumatic Brain Injury? 194 Chronic Traumatic Encephalopathy 197 TBI in the Military 198 References 199 Chapter 11: What’s going on Now? 204 Vitamin E 204 Medications in the Pipeline 205 Diagnosis 208 Biomarkers and the Alzheimer’s Disease Neuroimaging Initiative Study 213 Studying the Disease 215 References 217 Chapter 12: Novel Therapies 220 Stem Cells 220 Lifestyle Modifications 222 Genetic Modification and Personalized Medicine 231 Low-Level Light Therapy 232 Marijuana (THC) 236 THC and Neurogenesis 238 THC and Inflammation 239 Music Therapy 240 References 244 Chapter 13: How Can We Solve the Problem? 250 Caregiving 251 Comprehensive and Integrative Care Clinics 253 Risk Stratification 253 Risk Reduction and Management 255 Early (Correct) Diagnosis 256 Prophylactic Treatment 257 Diet 258 References 261 Chapter 14: What Resources Exist? 264 Global Resources 265 Federal Resources (Lobbying) to Fund Alzheimer’s Research Programs and Scientists 268 Organizational and Support Groups for Families 269 References 272 Acknowledgements 274 Note to Readers 276 Glossary/Abbreviations 278 Index 284

The book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a "global" perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world.

Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research.

Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease.

Dr. Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective.

This book with appeal to a wide audience, regardless of their scientific or educational background.

Contents:

• About the Authors
• Building a Community
• Foreword
• Preface
• Quick Reference Guide
• Introduction, History, and Overview:
  • Introduction to the Brain and Nervous System
  • Dysfunction
  • Senility and Normal Aging
  • What is Dementia?
  • Introduction to Alzheimer's Disease
  • Epidemiology of Alzheimer's Disease
  • The History of Alzheimer's Disease
  • An Interesting Link
• Novel Therapies and Future Directions:
  • Surgical Treatments for Dementia
  • Is There a Link to Traumatic Brain Injury?
  • What's Going on Now?
  • Novel Therapies
  • How Can We Solve the Problem?
  • What Resources Exist?
• Acknowledgements
• Note to Readers
• Glossary/Abbreviations
• Index

Readership: Interested lay public.
The book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a "global" perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world. Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research. Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease. Dr. Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective. This book with appeal to a wide audience, regardless of their scientific or educational background. Contents: About the Authors Building a Community Foreword Preface Quick Reference Guide Introduction, History, and Overview: Introduction to the Brain and Nervous System Dysfunction Senility and Normal Aging What is Dementia? Introduction to Alzheimer's Disease Epidemiology of Alzheimer's Disease The History of Alzheimer's Disease An Interesting Link Novel Therapies and Future Directions: Surgical Treatments for Dementia Is There a Link to Traumatic Brain Injury? What's Going on Now? Novel Therapies How Can We Solve the Problem? What Resources Exist? Acknowledgements Note to Readers Glossary/Abbreviations Index Readership: Interested lay public