Aldehyde Dehydrogenases: From Alcohol Metabolism to Human Health and Precision Medicine (Advances in Experimental Medicine and Biology Book 1193)

"This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource"--Publisher's description Front Matter ....Pages i-xx Role of Alcohol Oxidative Metabolism in Its Cardiovascular and Autonomic Effects (Mahmoud M. El-Mas, Abdel A. Abdel-Rahman)....Pages 1-33 Environmental Aldehyde Sources and the Health Implications of Exposure (Pritam Sinharoy, Stacy L. McAllister, Megana Vasu, Eric R. Gross)....Pages 35-52 ALDH2 and Cardiovascular Disease (Che-Hong Chen, Julio C. B. Ferreira, Daria Mochly-Rosen)....Pages 53-67 The Bidirectional Effect of Defective ALDH2 Polymorphism and Disease Prevention (Akiko Matsumoto)....Pages 69-87 Aldehyde Dehydrogenase 2 and Heart Failure (Wenjia Li, Cheng Shen, Lei Yin, Junbo Ge, Aijun Sun)....Pages 89-106 Mitochondrial Aldehyde Dehydrogenase in Myocardial Ischemic and Ischemia-Reperfusion Injury (Jie Ding, Zheng Yang, Heng Ma, Hao Zhang)....Pages 107-120 Association of East Asian Variant Aldehyde Dehydrogenase 2 Genotype (ALDH2*2*) with Coronary Spasm and Acute Myocardial Infarction (Hirofumi Yasue, Yuji Mizuno, Eisaku Harada)....Pages 121-134 Aldehyde Dehydrogenases Genetic Polymorphism and Obesity: From Genomics to Behavior and Health (Cheng Hu)....Pages 135-154 Aldehyde Dehydrogenase (ALDH) 2 in Diabetic Heart Diseases (Srikar Munukutla, Guodong Pan, Suresh S. Palaniyandi)....Pages 155-174 The Role of ALDH2 in Sepsis and the To-Be-Discovered Mechanisms (Jiaojiao Pang, Yue Zheng, Qi Han, Ying Zhang, Ruru Sun, Jiali Wang et al.)....Pages 175-194 ALDH2 and Stroke: A Systematic Review of the Evidence (Haixia Xu, Yingmei Zhang, Jun Ren)....Pages 195-210 Targeting ALDH2 in Atherosclerosis: Molecular Mechanisms and Therapeutic Opportunities (Sai Ma, Feng Cao)....Pages 211-220 ALDH2 and Cancer Therapy (Li-Shun Wang, Zhao-Xia Wu)....Pages 221-228 ALDH2 Polymorphism and Ethanol Consumption: A Genetic-Environmental Interaction in Carcinogenesis (Mingjie Yang, Yingmei Zhang, Jun Ren)....Pages 229-236 Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link? (Ne Natalie Wu, Jun Ren)....Pages 237-253