Alcoholic Hepatitis - ECAB Clinical Update: Gastroenterology/Hepatology

Alcoholic hepatitis involves an acute or chronic inflammation of liver occurring as a consequence of alcohol abuse The pathological changes occur in 3 stages namely, fatty liver, alcoholic hepatitis and cirrhosis, with the final stage traditionally considered to be irreversible Alcoholic liver disease is responsible for a significant number of premature deaths per annum all around the globe There is an urgent need to educate the masses about the hazards of alcohol abuse An efficient system to encourage and prolong the period of alcohol abstinence is the need of the hour The importance of lifestyle modifications like weight reduction and cessation of smoking in the progression of liver disease needs to be communicated to the patients and the medical community as well Moreover, realization of the role of nutrition in the management and recovery of ALD would enhance the treatment strategies for this condition This book has been designed to update the readers on the important aspects of ALD and is a step forward to enable the society in combating the social and economic losses that occur as a result of alcohol abuse The book has stressed upon various aspects of ALD like the role of nutrition, epidemiology and pathogenesis, and the possible therapeutic strategies involved Supportive case scenarios have also been incorporated with relevance to the topics covered under the book Overall, the book presents to the readers an excellent compilation of clinically applicable literature sourced from the most acclaimed physicians in the country Front Cover Title page ECAB Clinical Update:Gastroenterology/Hepatology Copyright About the Authors ECAB Clinical Update Information Contents Introduction Nutrition and Alcoholic Liver Disease Malnutrition in Alcoholics Role of Oxidants in Pathogenesis of Alcoholic Liver Disease Role of Iron in Alcoholic Liver Disease Mechanism of Damage by Iron Interaction of Diet, Ethanol, and Immune Function Nutritional Aspects Implication of Nutrition in Management of Alcoholic Liver Disease Alcohol's Effects on Digestion and Absorption of Essential Nutrients Amino Acids and Proteins Vitamins Effects of Malnutrition Nutritional Assessment Nutritional Management of Alcoholic Liver Disease Management of Nutritional Deficiencies Case Study Nutrition and Alcoholic Liver Disease Case Study 1 Alcoholic Liver Disease: Epidemiology and Pathogenesis Epidemiology Risk Factors Hepatitis C Infection Obesity Cigarette Smoking Pathogenesis Pathogenesis of Alcoholic Liver Disease and Cirrhosis Biochemistry Cytokines Acetaldeyde Oxidative Stress Hypoxia Autoimmune Reactions Recent Advances Mitochondrial Dysfunction Impaired Proteasome Function Abnormal Metabolism of Methionine, S-Adenosylmethionine and Folate Kupffer Cell Activation and Dysregulated Cytokine Production Immune and Inflammatory Mechanisms Gender Diabetes Mechanisms of Hepatic Fibrosis Alcoholic Liver Disease in India Case Studies Alcoholic Liver Disease: Epidemiology and Pathogenesis Case study 1 History Clinical Diagnosis Investigations Final Diagnosis Treatment Outcome Discussion Case Study 2 History Clinical Diagnosis Relevant Investigations Diagnosis Treatment Outcome Discussion Management of Alcoholic Hepatitis What is Alcoholic Liver Disease? Mechanisms of Alcohol-Related Liver Injury Treatment Modalities for Alcoholic Liver Disease Abstinence Acute Alcoholic Hepatitis Nutritional Support Corticosteroids Oxpentifylline (Pentoxifylline) Anti-TNF Therapy Antioxidants Propylthiouracil Colchicine Metadoxine Transplantation Case Study Management of Alcoholic Hepatitis Case 1 Genetics of Alcoholic Liver Disease Genetic Predisposition to Alcoholism Genetic Predisposition to Alcoholic Hepatitis and Cirrhosis Genetic Predisposition to Hepatocellular Carcinoma in Alcoholic Cirrhosis Genetic Variation to Response to Treatment with Naltrexone Local Experience Future Summary Forthcoming Books