Alcohol Intoxication and Withdrawal I: Experimental Studies (Advances in Experimental Medicine and Biology, 35)

The contributions to this volume clearly indicate the momentum, quality, liveliness and diversity of the research effort being di­ rected toward deepening our understanding of tqe alcohol withdrawal syndrome. This area of study has gained increasing interest and attention to the point where it seemed reasonable to devote a spe­ cial section to it at the 30th International Congress for Alcoholism and Drug Dependence in Amsterdam in September, 1972. Our goal was to share our most recent findings and stimulate others to join in the effort. With few exceptions, the papers in this publication present new data. It had been hoped that the volume would appear by the end of 1972. However, the eagerness of many of the contributors to extend their investigations made this target date impossible. Several of the papers were not presented in the section but were presented elsewhere in the Congress. However, because of their particular relevance to the topic they have been included with the generous consent of the authors. Front Matter....Pages i-xiv Front Matter....Pages 1-1 Biological Models of Alcohol Tolerance and Physical Dependence....Pages 3-14 Neurochemical Aspects of Tolerance to and Dependence on Ethanol....Pages 15-31 A Role for Tetrahydroisoquinoline Alkaloids as False Adrenergic Neurotransmitters in Alcoholism....Pages 33-44 Addiction to Barbiturates and Ethanol: Possible Biochemical Mechanisms....Pages 45-55 Front Matter....Pages 57-57 Possible Role of Microsomal Changes Induced by Ethanol Intake in the Development of Tolerance and Dependence....Pages 59-77 Effects of Ethanol on Liver Metabolism....Pages 79-104 Tryptophan Pyrrolase in Ethanol Administration and Withdrawal....Pages 105-123 The Metabolic Basis of Ethanol Toxicity....Pages 125-143 Biochemical Changes in Mitochondria as a Mechanism in Metabolic Tolerance to Ethanol....Pages 145-166 Hypothalamic-Pituitary-Adrenal Function in Chronic Alcoholics....Pages 167-179 Influence of Two Tetrahydrocannabinols (THC’s) on the Activity of Biotransformation Enzymes....Pages 181-194 Front Matter....Pages 195-195 Chronic Ingestion Techniques for the Production of Physical Dependence on Ethanol....Pages 197-211 Alcohol Oral Self-Administration in Rats: Attempts to Elicit Excessive Intake and Dependence....Pages 213-224 Evaluation of a Polydipsia Technique to Induce Alcohol Consumption in Monkeys....Pages 225-243 Effects of Electrical Stimulation of the Lateral Hypothalamus on Ethanol Consumption....Pages 245-257 Front Matter....Pages 259-259 Chronic Alcoholism, Alcohol and Sleep....Pages 261-279 Correlation of Urinary Biogenic Amines with Sleep Stages in Chronic Alcoholization and Withdrawal....Pages 281-289 Sleep Changes Induced by 4 and 6 Days of Experimental Alcoholization and Withdrawal in Humans....Pages 291-304 Hallucinations During Experimental Intoxication....Pages 305-319 Sensory Superactivity....Pages 321-330 Front Matter....Pages 331-331 Short-Term Memory Function in Alcohol Addicts During Intoxication....Pages 333-344 The Effects of Alcohol on the Somatosensory Evoked Potentials in Man....Pages 345-350 Affective Changes During 6 Days of Experimental Alcoholization and Subsequent Withdrawal....Pages 351-363 An Improved Quantitative System for Assessing the Acute Alcoholic Psychoses and Related States (TSA and SSA)....Pages 365-376 Observations on the Prevalence of the Signs and Symptoms Associated with Withdrawal During Continuous Observation of Experimental Intoxication and Withdrawal in Humans....Pages 377-406 Recovery Function and Clinical Symptomatology in Acute Alcoholization and Withdrawal....Pages 407-413 Back Matter....Pages 415-422