Airway Smooth Muscle Biology And Pharmacology In Asthma And Copd: Biology And Pharmacology

In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management. Authoritative update on key mechanisms of airway constriction in Asthma and COPD Relates latest research to bronchodilator therapy Multi-contributed text, co-coordinated by two of the leading authorities in the field. cover......Page 1 Frontmatter.pdf......Page 2 1 Biophysical Basis of Airway Smooth Muscle Contraction and Hyperresponsiveness in Asthma......Page 14 2 Dynamics of Cytoskeletal and Contractile Protein Organization An Emerging Paradigm for Airway Smooth Muscle Contraction......Page 44 3 Airway Smooth Muscle Role in Airway Constrictor Hyperresponsiveness......Page 65 4 Airway Smooth Muscle Phenotypic and Functional Plasticity......Page 82 5 Airway Smooth Muscle Proliferation Insights into Mechanisms Regulating Airway Smooth Muscle Mass......Page 100 6 Airway Smooth Muscle Bidirectional Interactions with Extracellular Matrix......Page 116 7 Airway Smooth Muscle Interaction with Mast Cells......Page 138 8 Airway Smooth Muscle Synthesis of Inflammatory Mediators......Page 151 9 Airway Smooth Muscle in Experimental Models......Page 169 10 Altered Properties of Airway Smooth Muscle in Asthma......Page 190 11 The Airway Smooth Muscle in Chronic Obstructive Pulmonary Disease (COPD)......Page 209 12 Glucocorticoid Actions on Airway Smooth Muscle......Page 242 13 B2 Adrenergic Receptors Effects on Airway Smooth Muscle......Page 262 14 Asthma Treatments Effects on the Airway Smooth Muscle......Page 283 Colour Plates......Page 309 Index......Page 313 "Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management." (Doody's Reviews, March 2009). Airway Smooth Muscle in Asthma and COPD is the first book of its kind that focuses entirely on the airway smooth muscle as the prime abnormality in airways diseases such as asthma