Airway Mucus: Basic Mechanisms And Clinical Perspectives (respiratory Pharmacology And Pharmacotherapy)

Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas. Front Matter....Pages I-X Airway Surface Liquid: Concepts and Measurements....Pages 1-17 Structure and Biochemistry of Human Respiratory Mucins....Pages 19-39 Airway Mucin Genes and Gene Products....Pages 41-66 The Microanatomy of Airway Mucus Secretion....Pages 67-89 Mechanisms Controlling Airway Ciliary Activity....Pages 91-116 Rheological Properties and Hydration of Airway Mucus....Pages 117-147 Goblet Cells: Physiology and Pharmacology....Pages 149-177 Airway Submucosal Glands: Physiology and Pharmacology....Pages 179-210 Mucus—Bacteria Interactions....Pages 211-225 Experimental Induction of Goblet Cell Hyperplasia In Vivo ....Pages 227-273 Mucus Hypersecretion and Its Role in the Airway Obstruction of Asthma and Chronic Obstructive Pulmonary Disease....Pages 275-300 Mucus and Airway Epithelium Alterations in Cystic Fibrosis....Pages 301-326 Drug—Mucus Interactions....Pages 327-339 Therapeutic Approaches to the Lung Problems in Cystic Fibrosis....Pages 341-364 Therapeutic Approaches to Airway Mucous Hypersecretion....Pages 365-383 Back Matter....Pages 385-388