Ageing and dementia : [papers and posters presented at the 5th international symposium of the research initiative EBEWE, held in october 17-19, in Graz

Ageing and dementia are closely related conditions. Increasing age of the general population causes increasing incidence of dementing disorders in later life, although cognitive impairment is not necessarily a consequence of advancing age. The book presents the papers of the International Symposium on Ageing and Dementia, October 17–19, 1997 in Graz, where internationally renowned experts in the field of ageing and dementia gave an overview of the current knowledge about the epidemiology, pathomorphology, clinical diagnosis and course of brain ageing processes and related dementing disorders, biochemical markers and imaging procedures for the diagnosis of Alzheimer’s disease and current approaches to a successful treatment of dementia. "... this book will be of interest to clinicians with previous experience of clinical dementia assessements, and to researchers who want a comprehensive update on research areas of dementia with which they are less familiar. It will also be of interest to those following the development of neurotrophe factors for treatment of dementia who need an extensive introduction to the preclinical studies of Cerebrolysin®. The book will be fairly useful as a textbook for clinicians who are learning about clinical dementia assessments for the first time.” Acta Psychiatrica Scandinavica Front Matter....Pages I-VIII Anti-oxidants and cognitive function: a review of clinical and epidemiologic studies....Pages 1-8 Brain abnormalities in the elderly: frequency and predictors in the United States (the Cardiovascular Health Study)....Pages 9-16 Apolipoprotein E genotype, atherosclerosis, and cognitive decline: the Rotterdam study....Pages 17-29 The spectrum of age-associated brain abnormalities: their measurement and histopathological correlates....Pages 31-39 Cognitive correlates of cerebral white matter changes....Pages 41-67 Concepts on the prognostic significance of white matter changes....Pages 69-78 Difficulties in the clinical diagnosis of vascular dementia and dementia of the Alzheimer type — comparison of clinical classifications....Pages 79-90 Problems of differential diagnosis between depressive pseudodementia and Alzheimer’s disease....Pages 91-95 The neuropathological diagnosis of Alzheimer disease....Pages 97-118 The progression of the lesions in Alzheimer disease: insights from a prospective clinicopathological study....Pages 119-126 Evolution of neuronal changes in the course of Alzheimer’s disease....Pages 127-140 The cytoskeleton in Alzheimer disease....Pages 141-145 Mechanisms of synaptic pathology in Alzheimer’s disease....Pages 147-158 Proteolytic processing of Alzheimer’s disease associated proteins....Pages 159-167 Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles....Pages 169-180 Presenilins and Alzheimer’s disease: the role of Aβ42....Pages 181-184 Biological markers for the diagnosis of Alzheimer’s disease....Pages 185-197 Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer’s disease....Pages 199-207 Cerebrospinal fluid levels of Aβ42 and tau: potential markers of Alzheimer’s disease....Pages 209-221 Combination of the different biological markers for increasing specificity of in vivo Alzheimer’s testing....Pages 223-235 Positron emission tomography for diagnosis of Alzheimer’s disease and vascular dementia....Pages 237-250 Current diagnostic methods and outcome variables for clinical investigation of Alzheimer’s disease....Pages 251-254 Perspectives in clinical Alzheimer’s disease research and the development of antidementia drugs....Pages 255-275 The role of glutamate in dementia....Pages 277-287 Neurotrophic activities and therapeutic experience with a brain derived peptide preparation....Pages 289-298 Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreactivity after focal ischemia in rats....Pages 299-311 The influence of Cerebrolysin® and E021 on spatial navigation of 24-month-old rats....Pages 313-321 Molecular regulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors....Pages 323-331 Antioxidant systemic effect of short-term Cerebrolysin® administration....Pages 333-341 Can Cerebrolysin® influence chronic deterioration of spatial learning and memory?....Pages 343-349 Cerebrolysin® protects isolated cortical neurons from neurodegeneration after brief histotoxic hypoxia....Pages 351-361 Further evidence that Cerebrolysin® protects cortical neurons from neurodegeneration in vitro....Pages 363-372 Influence of BDNF and FCS on viability and programmed cell death (PCD) of developing cortical chicken neurons in vitro....Pages 373-384 Dose-dependent effects of Cerebrolysin® on EEG and short term memory of healthy volunteers during control and hyperventilation induced cerebral ischemia....Pages 385-398 Back Matter....Pages 399-407 Ageing and dementia are closely related conditions. Increasing age of general population causes increasing incidence of dementing disorders in later life, although cognitive impairment is not necessarily a consequence of advancing age. This book presents the papers of the International Symposium on Ageing and Dementia, October 17-19, 1997 in Graz.