Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences)

This volume presents breakthroughs and techniques in affinity capillary electrophoresis to measure and determine the physicochemical and thermodynamic parameters of drug compounds. It discusses strategies to explore and characterize interactions to facilitate developments in controlled drug delivery and targeting. Outlines the possibilities of applying affinity capillary electrophoresis (ACE) to controlled drug delivery and drug targeting. The 14 chapters review the principles of capillary electrophoresis, then explore the use of ACE to characterize the physiochemical properties of drugs, and present methods based on ACE for studying interactions of drugs and pharmaceutical vehicle systems with biological structures. Topics include the affinity of drugs to excipients, interactions between chiral drugs and cyclodextrins, the binding of drugs to receptor and plasma proteins, and the characterization of immunoreactions. Most of the chapters overview the results of published studies rather than describe the technical details. Annotation (c)2003 Book News, Inc., Portland, OR (booknews.com) This reference presents the most recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds. The authors offer strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate developments in controlled drug delivery and targeting. The book contains current applications and procedures to identify binding constants between drugs, biological structures, proteins, nucleic acids, and plasmids, increase drug bioavailability, enhance the permeability, solubility, strength, and function of drug formulations, examine protein-protein exchanges and reactions, and calculate pKa values. Over the last 10 years, capillary electrophoresis has matured into a powerful analysis technique focusing on water-soluble ionic analytes.