Advances in Stem Cell Therapy: Bench to Bedside (Stem Cell Biology and Regenerative Medicine Book 0)

The book reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp. The book starts with an overview of experimental protocols applied to generate insulin secreting cells, neural cells, heart cells, and other tissue specific cells ex vivo and in experimental animals. This is followed by exhaustive review of clinical trials in these pathologies. It continues with a comparison of the merits of successful transplantation in humans versus animal experimentation, and highlights the most promising clinical applications in the field. Special chapters are devoted to the topic of tissue engineering and modern synthetic and biological scaffolds. It is essential reading for scientists and researchers in tissue engineering and stem cell research as well as clinicians who are involved in developing or testing stem cell therapies. Front Matter....Pages i-xvi Front Matter....Pages 1-1 Hematopoietic Stem Cell Transplantation in Pediatric Diseases....Pages 3-18 Stem Cell Therapy in Diabetes Mellitus....Pages 19-30 Stem Cell Therapies in Neurological Disorders....Pages 31-59 Stem Cells in Diseases of Aging....Pages 61-75 Therapeutic Prospects of Stem Cells in Benign Urological Conditions....Pages 77-93 Clinical Applications of Stem Cells in Women’s Reproductive Health....Pages 95-114 Front Matter....Pages 115-115 Adipose-Derived Stem Cell-Based Therapies in Regenerative Medicine....Pages 117-138 Advances in Umbilical Cord Blood Therapy: Hematopoietic Stem Cell Transplantation and Beyond....Pages 139-168 Front Matter....Pages 169-169 Dental Pulp Stem Cells in Tissue Engineering and Regenerative Medicine: Opportunities for Translational Research....Pages 171-196 Stem Cell Therapy and Tissue Engineering in Urogenital Diseases....Pages 197-223 Stem Cell Therapy for Autoimmune Disease....Pages 225-248 Treatment of Hepatic Malignances and Disorders: The Role of Liver Bioengineering....Pages 249-276 Advances in Micro- and Nanotechnologies for Stem Cell-Based Translational Applications....Pages 277-302 Back Matter....Pages 303-310 This text reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp. The book starts with an overview of experimental protocols applied to generate insulin secreting cells, neural cells, heart cells, and other tissue specific cells ex vivo and in experimental animals. This is followed by exhaustive review of clinical trials in these pathologies. It continues with a comparison of the merits of successful transplantation in humans versus animal experimentation, and highlights the most promising clinical applications in the field