Advances in Respiratory Cancerogenesis (Advances in Experimental Medicine and Biology Book 911)

"Lung cancer is the leading cause of mortality worldwide, with a low survival rate. Carcinogenesis generally requires a constellation of entwined steps, involving both innate cellular and environmental factors. This book shares the updated knowledge on the origin and development of cancer through genotypic changes which upset the physiological balance between cell proliferation, differentiation, growth control, and apoptosis. The emphasis is put on the role of microRNA proteins involved in the cellular processes above outlined. Cognitive changes, related to dysregulated cellular mechanisms in cancer cells, as yet unchartered area of research, also are tackled. A better understanding of the molecular and cellular biology of lung cancer is the key source of breakthroughs in the diagnosis and prognosis, and finding more effective therapies that target specific mutations. The book provides a source of current facts and trends in clinical research and practice. It will be of interest to clinicians, researchers, and other medical professionals"--Back cover Front Matter....Pages i-viii The Role of Dysregulated MicroRNA Expression in Lung Cancer....Pages 1-8 Laryngeal Cancer: 12-Year Experience of a Single Center....Pages 9-16 Polymorphisms of Selected DNA Repair Genes and Lung Cancer in Chromium Exposure....Pages 17-22 Associations of CYP1A2 Polymorphisms with the Risk Haplotypes in Lung Cancer in the Slovak Population....Pages 23-32 Impact of Endobronchial Ultrasound Guided Transbronchial Needle Aspiration on Diagnostic Yield of Bronchoscopy in Patients with Mediastinal Lymph Node Enlargement....Pages 33-43 The Effect on Cognition of Mitochondrial Respiratory System Proteins in Peripheral Blood Mononuclear Cells in the Course of Lung Cancer....Pages 45-52 Lung Cancer and Multiple Neoplasms: A Retrospective Analysis....Pages 53-58 Humoral Immune Response against Neural Antigens and Its Effects on Cognition in Lung Cancer Patients....Pages 59-66 Active Case Finding Among Homeless People as a Means of Reducing the Incidence of Pulmonary Tuberculosis in General Population....Pages 67-76 Cryptogenic Organizing Pneumonia: IL-1β, IL-6, IL-8, and TGF- β1 Serum Concentrations and Response to Clarithromycin Treatment....Pages 77-85 Back Matter....Pages 87-87